OBJECTIVE: To determine whether smoking reduces the progression of osteoarthritis (OA). METHODS: Observational studies examining smoking and progression of OA were systematically searched through Medline (1948-), EMBase (1980-), Web of Science, PubMed, and Google and relevant references. The search was last updated in May 2012. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were directly retrieved or calculated. Current standards for reporting meta-analyses of observational studies (Meta-Analysis of Observational Studies in Epidemiology) were followed. Quality-related aspects such as study design, setting, sample selection, definition of progression, and confounding bias were recorded. Stratified and meta-regression analyses were undertaken to examine the covariates. RESULTS: Sixteen studies (976,564 participants) were identified from the literature. Overall, there was no significant association between smoking and progression of OA (OR 0.92; 95% CI 0.83, 1.02). There was moderate heterogeneity of results (I(2) = 57.3%, P = 0.0024). Subgroup analyses showed some associations of marginal significance; however, meta-regression did not confirm any significant results. CONCLUSION: There is no compelling evidence that smoking has a protective effect on the progression of OA. The results concur with a previous meta-analysis published by this group that showed no association between smoking and incidence of OA. Taken together, smoking does not appear to reduce either the incidence or progression of OA.
OBJECTIVE: To determine whether smoking reduces the progression of osteoarthritis (OA). METHODS: Observational studies examining smoking and progression of OA were systematically searched through Medline (1948-), EMBase (1980-), Web of Science, PubMed, and Google and relevant references. The search was last updated in May 2012. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were directly retrieved or calculated. Current standards for reporting meta-analyses of observational studies (Meta-Analysis of Observational Studies in Epidemiology) were followed. Quality-related aspects such as study design, setting, sample selection, definition of progression, and confounding bias were recorded. Stratified and meta-regression analyses were undertaken to examine the covariates. RESULTS: Sixteen studies (976,564 participants) were identified from the literature. Overall, there was no significant association between smoking and progression of OA (OR 0.92; 95% CI 0.83, 1.02). There was moderate heterogeneity of results (I(2) = 57.3%, P = 0.0024). Subgroup analyses showed some associations of marginal significance; however, meta-regression did not confirm any significant results. CONCLUSION: There is no compelling evidence that smoking has a protective effect on the progression of OA. The results concur with a previous meta-analysis published by this group that showed no association between smoking and incidence of OA. Taken together, smoking does not appear to reduce either the incidence or progression of OA.
Authors: Stella G Muthuri; Weiya Zhang; Rose A Maciewicz; Kenneth Muir; Michael Doherty Journal: Arthritis Res Ther Date: 2015-02-05 Impact factor: 5.156
Authors: Hilde Apold; Haakon E Meyer; Lars Nordsletten; Ove Furnes; Valborg Baste; Gunnar B Flugsrud Journal: BMC Musculoskelet Disord Date: 2014-06-23 Impact factor: 2.362
Authors: Yi Zhang; Chao Zeng; Jie Wei; Hui Li; Tuo Yang; Ye Yang; Zhen-han Deng; Xiang Ding; Guanghua Lei Journal: BMJ Open Date: 2016-03-11 Impact factor: 2.692
Authors: Sarah R Kingsbury; Nadia Corp; Fiona E Watt; David T Felson; Terence W O'Neill; Cathy A Holt; Richard K Jones; Philip G Conaghan; Nigel K Arden Journal: Rheumatology (Oxford) Date: 2016-04-15 Impact factor: 7.580
Authors: Shelby S Yamamoto; Elaine Yacyshyn; Gian S Jhangri; Arvind Chopra; Divya Parmar; C Allyson Jones Journal: PLoS One Date: 2019-12-27 Impact factor: 3.240