BACKGROUND: To report a single institutional experience with definitive radiation therapy alone for human papillomavirus (HPV)-positive head and neck cancer. METHODS: A total of 67 patients were treated by radiation therapy alone to a median dose of 70 Gy (range, 66-72 Gy) for squamous cell carcinoma of the head and neck. Paraffin-embedded, formalin-fixed pretreatment tumor tissues were used to establish HPV-positivity using standardized techniques of immunohistochemistry for p16 and polymerase chain reaction for HPV. RESULTS: In all, 23 patients with HPV-positive cancers were identified. With a median follow-up of 28 months (range, 6-85 months), the 3-year actuarial rates of overall survival, locoregional control, and distant metastasis-free survival were 83%, 90%, and 88%, respectively. CONCLUSION: These findings attest to the exquisite radiosensitivity of HPV-positive head and neck cancer. The clinical outcomes observed from this selected series compare favorably with historical controls treated by more intensive chemoradiotherapy strategies.
BACKGROUND: To report a single institutional experience with definitive radiation therapy alone for human papillomavirus (HPV)-positive head and neck cancer. METHODS: A total of 67 patients were treated by radiation therapy alone to a median dose of 70 Gy (range, 66-72 Gy) for squamous cell carcinoma of the head and neck. Paraffin-embedded, formalin-fixed pretreatment tumor tissues were used to establish HPV-positivity using standardized techniques of immunohistochemistry for p16 and polymerase chain reaction for HPV. RESULTS: In all, 23 patients with HPV-positive cancers were identified. With a median follow-up of 28 months (range, 6-85 months), the 3-year actuarial rates of overall survival, locoregional control, and distant metastasis-free survival were 83%, 90%, and 88%, respectively. CONCLUSION: These findings attest to the exquisite radiosensitivity of HPV-positive head and neck cancer. The clinical outcomes observed from this selected series compare favorably with historical controls treated by more intensive chemoradiotherapy strategies.
Authors: K Kian Ang; Jonathan Harris; Richard Wheeler; Randal Weber; David I Rosenthal; Phuc Felix Nguyen-Tân; William H Westra; Christine H Chung; Richard C Jordan; Charles Lu; Harold Kim; Rita Axelrod; C Craig Silverman; Kevin P Redmond; Maura L Gillison Journal: N Engl J Med Date: 2010-06-07 Impact factor: 91.245
Authors: Jessica H Maxwell; Bhavna Kumar; Felix Y Feng; Francis P Worden; Julia S Lee; Avraham Eisbruch; Gregory T Wolf; Mark E Prince; Jeffrey S Moyer; Theodoros N Teknos; Douglas B Chepeha; Jonathan B McHugh; Susan G Urba; Jay Stoerker; Heather M Walline; David M Kurnit; Kitrina G Cordell; Samantha J Davis; Preston D Ward; Carol R Bradford; Thomas E Carey Journal: Clin Cancer Res Date: 2010-02-09 Impact factor: 12.531
Authors: Ervinna Pang; Naomi C Delic; Angela Hong; Mei Zhang; Barbara R Rose; J Guy Lyons Journal: Int J Radiat Oncol Biol Phys Date: 2010-11-23 Impact factor: 7.038
Authors: Claude A Fischer; Inti Zlobec; Edith Green; Simone Probst; Claudio Storck; Alessandro Lugli; Luigi Tornillo; Markus Wolfensberger; Luigi M Terracciano Journal: Int J Cancer Date: 2010-03-01 Impact factor: 7.396
Authors: Jens P Klussmann; Jeroen J Mooren; Martin Lehnen; Sandra M H Claessen; Markus Stenner; Christian U Huebbers; Soenke J Weissenborn; Inga Wedemeyer; Simon F Preuss; Jos M J A A Straetmans; Johannes J Manni; Anton H N Hopman; Ernst-Jan M Speel Journal: Clin Cancer Res Date: 2009-02-17 Impact factor: 12.531
Authors: Anjali K Gupta; John H Lee; Werner W Wilke; Harry Quon; Gareth Smith; Amit Maity; John M Buatti; Douglas R Spitz Journal: Int J Radiat Oncol Biol Phys Date: 2009-07-01 Impact factor: 7.038
Authors: William C Spanos; Paul Nowicki; Dong Wook Lee; Andrew Hoover; Bruce Hostager; Anjali Gupta; Mary E Anderson; John H Lee Journal: Arch Otolaryngol Head Neck Surg Date: 2009-11
Authors: Mitchell Machtay; Jennifer Moughan; Andrew Trotti; Adam S Garden; Randal S Weber; Jay S Cooper; Arlene Forastiere; K Kian Ang Journal: J Clin Oncol Date: 2008-06-16 Impact factor: 44.544
Authors: Adepitan A Owosho; SaeHee K Yom; Zhiqiang Han; Kevin Sine; Nancy Y Lee; Joseph M Huryn; Cherry L Estilo Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Date: 2016-07-19
Authors: Adepitan A Owosho; C Jillian Tsai; Ryan S Lee; Haley Freymiller; Arvin Kadempour; Spyridon Varthis; Adi Z Sax; Evan B Rosen; SaeHee K Yom; Joseph Randazzo; Esther Drill; Elyn Riedel; Snehal Patel; Nancy Y Lee; Joseph M Huryn; Cherry L Estilo Journal: Oral Oncol Date: 2016-12-03 Impact factor: 5.337
Authors: Adepitan A Owosho; Luciana M Pedreira Ramalho; Haley I Rosenberg; SaeHee K Yom; Esther Drill; Elyn Riedel; C Jillian Tsai; Nancy Y Lee; Joseph M Huryn; Cherry L Estilo Journal: J Craniomaxillofac Surg Date: 2016-06-16 Impact factor: 2.078
Authors: P Boscolo-Rizzo; A Del Mistro; F Bussu; V Lupato; L Baboci; G Almadori; M C DA Mosto; G Paludetti Journal: Acta Otorhinolaryngol Ital Date: 2013-04 Impact factor: 2.124