Literature DB >> 23334892

Serum levels of heat shock protein 27 in patients with acute ischemic stroke.

Gabriella Gruden1, Federica Barutta, Irene Catto, Giovanni Bosco, Maria Giovanna Caprioli, Silvia Pinach, Paolo Fornengo, Paolo Cavallo-Perin, Ottavio Davini, Paolo Cerrato, Graziella Bruno.   

Abstract

Expression of intracellular heat shock protein 27 (Hsp27) rises in the brain of animal models of cerebral ischemia and stroke. Hsp27 is also released into the circulation and the aim of the present study was to investigated if serum Hsp27 (sHsp27) levels are altered in patients with acute ischemic stroke. sHsp27 was measured in 15 patients with acute ischemic stroke and in 14 control subjects comparable for age, sex, and cardiovascular risk factors. In patients, measurements were performed at admission and 1, 2, and 30 days thereafter. At admission, mean sHsp27 values were threefold higher in patients than in controls. In patients, sHsp27 values dropped after 24 h, rose again at 48 h, and markedly declined at 30 days, indicating the presence of a temporal trend of sHsp27 values following acute ischemic stroke.

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Year:  2013        PMID： 23334892      PMCID： PMC3682014          DOI： 10.1007/s12192-013-0403-5

Source DB:  PubMed          Journal:  Cell Stress Chaperones        ISSN： 1355-8145            Impact factor:   3.667


  14 in total

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Journal:  Cancer Res       Date:  2011-01-11       Impact factor: 12.701

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Journal:  J Cereb Blood Flow Metab       Date:  2009-12-09       Impact factor: 6.200

5.  Serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis.

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6.  Protective effect of post-ischaemic viral delivery of heat shock proteins in vivo.

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7.  Plasma concentration of heat shock protein 27 and risk of cardiovascular disease: a prospective, nested case-control study.

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Journal:  PLoS One       Date:  2009-03-10       Impact factor: 3.240

10.  The protective and therapeutic function of small heat shock proteins in neurological diseases.

Authors:  Sara E Brownell; Rachel A Becker; Lawrence Steinman
Journal:  Front Immunol       Date:  2012-05-01       Impact factor: 7.561
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  5 in total

1.  COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study.

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Journal:  Cell Stress Chaperones       Date:  2015-01-27       Impact factor: 3.667

Review 2.  Heat-Shock Proteins in Neuroinflammation.

Authors:  Brigitta Dukay; Bálint Csoboz; Melinda E Tóth
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Review 5.  Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective.

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  5 in total

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