Literature DB >> 23333798

Wnt pathway contributes to the protection by bone marrow stromal cells of acute lymphoblastic leukemia cells and is a potential therapeutic target.

Yang Yang1, Saradhi Mallampati, Baohua Sun, Jing Zhang, Sang-Bae Kim, Ju-Seog Lee, Yun Gong, Zhen Cai, Xiaoping Sun.   

Abstract

Leukemia cells are protected by various components of their microenvironment, including marrow stromal cells (MSCs). To understand the molecular mechanisms underlying this protection, we cultured acute lymphoblastic leukemia (ALL) cells with MSCs and studied the effect of the latter on the molecular profiling of ALL cells at the mRNA and protein levels. Our results indicated that activated Wnt signaling in ALL cells is involved in MSC-mediated drug resistance. Blocking the Wnt pathway sensitized the leukemia cells to chemotherapy and improved overall survival in a mouse model. Targeting the Wnt pathway may be an innovative approach to the treatment of ALL.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23333798      PMCID： PMC3880833          DOI： 10.1016/j.canlet.2012.11.056

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  31 in total

1.  p38MAPK inhibitors attenuate cytokine production by bone marrow stromal cells and reduce stroma-mediated proliferation of acute lymphoblastic leukemia cells.

Authors:  Shivashni S Gaundar; Kenneth F Bradstock; Linda J Bendall
Journal:  Cell Cycle       Date:  2009-09-16       Impact factor: 4.534

2.  Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells.

Authors:  Raoul Tibes; Yihua Qiu; Yiling Lu; Bryan Hennessy; Michael Andreeff; Gordon B Mills; Steven M Kornblau
Journal:  Mol Cancer Ther       Date:  2006-10       Impact factor: 6.261

3.  Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.

Authors:  Yoko Tabe; Linhua Jin; Yuko Tsutsumi-Ishii; Yuanyuan Xu; Teresa McQueen; Waldemar Priebe; Gordon B Mills; Akimichi Ohsaka; Isao Nagaoka; Michael Andreeff; Marina Konopleva
Journal:  Cancer Res       Date:  2007-01-15       Impact factor: 12.701

4.  Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

Authors:  Zhihong Zeng; Yue Xi Shi; Ismael J Samudio; Rui-Yu Wang; Xiaoyang Ling; Olga Frolova; Mark Levis; Joshua B Rubin; Robert R Negrin; Elihu H Estey; Sergej Konoplev; Michael Andreeff; Marina Konopleva
Journal:  Blood       Date:  2008-10-27       Impact factor: 22.113

5.  Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1.

Authors:  Y Zhu; Z Sun; Q Han; L Liao; J Wang; C Bian; J Li; X Yan; Y Liu; C Shao; R C Zhao
Journal:  Leukemia       Date:  2009-01-15       Impact factor: 11.528

6.  Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.

Authors:  Pascal Gelebart; Mona Anand; Hanan Armanious; Anthea C Peters; Jennifer Dien Bard; Hesham M Amin; Raymond Lai
Journal:  Blood       Date:  2008-09-11       Impact factor: 22.113

7.  Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells.

Authors:  Angela Colmone; Maria Amorim; Andrea L Pontier; Sheng Wang; Elizabeth Jablonski; Dorothy A Sipkins
Journal:  Science       Date:  2008-12-19       Impact factor: 47.728

8.  Wnt1 overexpression promotes tumour progression in non-small cell lung cancer.

Authors:  Cheng-Long Huang; Dage Liu; Shinya Ishikawa; Takashi Nakashima; Nariyasu Nakashima; Hiroyasu Yokomise; Kyuichi Kadota; Masaki Ueno
Journal:  Eur J Cancer       Date:  2008-09-13       Impact factor: 9.162

9.  Activation of Wnt/beta-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia.

Authors:  Naveed I Khan; Kenneth F Bradstock; Linda J Bendall
Journal:  Br J Haematol       Date:  2007-08       Impact factor: 6.998

10.  CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment.

Authors:  J Juarez; A Dela Pena; R Baraz; J Hewson; M Khoo; A Cisterne; S Fricker; N Fujii; K F Bradstock; L J Bendall
Journal:  Leukemia       Date:  2007-04-05       Impact factor: 11.528
View more
  41 in total

1.  MAPK signaling cascades mediate distinct glucocorticoid resistance mechanisms in pediatric leukemia.

Authors:  Courtney L Jones; Christy M Gearheart; Susan Fosmire; Cristina Delgado-Martin; Nikki A Evensen; Karen Bride; Angela J Waanders; Faye Pais; Jinhua Wang; Teena Bhatla; Danielle S Bitterman; Simone R de Rijk; Wallace Bourgeois; Smita Dandekar; Eugene Park; Tamara M Burleson; Pillai Pallavi Madhusoodhan; David T Teachey; Elizabeth A Raetz; Michelle L Hermiston; Markus Müschen; Mignon L Loh; Stephen P Hunger; Jinghui Zhang; Michael J Garabedian; Christopher C Porter; William L Carroll
Journal:  Blood       Date:  2015-08-31       Impact factor: 22.113

2.  Osteoblasts protect AML cells from SDF-1-induced apoptosis.

Authors:  Kimberly N Kremer; Amel Dudakovic; Meghan E McGee-Lawrence; Rachael L Philips; Allan D Hess; B Douglas Smith; Andre J van Wijnen; Judith E Karp; Scott H Kaufmann; Jennifer J Westendorf; Karen E Hedin
Journal:  J Cell Biochem       Date:  2014-06       Impact factor: 4.429

3.  Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells.

Authors:  Masaki Iwasa; Yasuo Miura; Aya Fujishiro; Sumie Fujii; Noriko Sugino; Satoshi Yoshioka; Asumi Yokota; Terutoshi Hishita; Hideyo Hirai; Akira Andoh; Tatsuo Ichinohe; Taira Maekawa
Journal:  Int J Hematol       Date:  2017-01-02       Impact factor: 2.490

4.  Role of MSC-derived galectin 3 in the AML microenvironment.

Authors:  Peter P Ruvolo; Vivian R Ruvolo; Jared K Burks; YiHua Qiu; Rui-Yu Wang; Elizabeth J Shpall; Leonardo Mirandola; Numsen Hail; Zhihong Zeng; Teresa McQueen; Naval Daver; Sean M Post; Maurizio Chiriva-Internati; Steven M Kornblau; Michael Andreeff
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2018-04-12       Impact factor: 4.739

Review 5.  Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.

Authors:  Sonali P Barwe; Anthony Quagliano; Anilkumar Gopalakrishnapillai
Journal:  Semin Oncol       Date:  2017-07-11       Impact factor: 4.929

6.  Fibroblast activation protein protects bortezomib-induced apoptosis in multiple myeloma cells through β-catenin signaling pathway.

Authors:  Fu-Ming Zi; Jing-Song He; Yi Li; Cai Wu; Wen-Jun Wu; Yang Yang; Li-Juan Wang; Dong-Hua He; Li Yang; Yi Zhao; Gao-Feng Zheng; Xiao-Yan Han; He Huang; Qing Yi; Zhen Cai
Journal:  Cancer Biol Ther       Date:  2014-07-21       Impact factor: 4.742

7.  Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.

Authors:  Saradhi Mallampati; Xiaohong Leng; Haiqing Ma; Jianfang Zeng; June Li; Haiying Wang; Kevin Lin; Yue Lu; Yang Yang; Baohua Sun; Yun Gong; Ju-Seog Lee; Marina Konopleva; Michael Andreeff; Ralph B Arlinghaus; Zhen Cai; Bingliang Fang; Haifa Shen; Xin Han; Cheryl F Hirsch-Ginsberg; Xiaolian Gao; Anurag N Paranjape; Sendurai A Mani; Karen Clise-Dwyer; Xiaoping Sun
Journal:  Blood       Date:  2015-02-23       Impact factor: 22.113

8.  Wnt inhibition leads to improved chemosensitivity in paediatric acute lymphoblastic leukaemia.

Authors:  Smita Dandekar; Eleny Romanos-Sirakis; Faye Pais; Teena Bhatla; Courtney Jones; Wallace Bourgeois; Stephen P Hunger; Elizabeth A Raetz; Michelle L Hermiston; Ramanuj Dasgupta; Debra J Morrison; William L Carroll
Journal:  Br J Haematol       Date:  2014-07-04       Impact factor: 6.998

9.  Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.

Authors:  Koichi Oshima; Hossein Khiabanian; Ana C da Silva-Almeida; Gannie Tzoneva; Francesco Abate; Alberto Ambesi-Impiombato; Marta Sanchez-Martin; Zachary Carpenter; Alex Penson; Arianne Perez-Garcia; Cornelia Eckert; Concepción Nicolas; Milagros Balbin; Maria Luisa Sulis; Motohiro Kato; Katsuyoshi Koh; Maddalena Paganin; Giuseppe Basso; Julie M Gastier-Foster; Meenakshi Devidas; Mignon L Loh; Renate Kirschner-Schwabe; Teresa Palomero; Raul Rabadan; Adolfo A Ferrando
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-21       Impact factor: 11.205

10.  Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome.

Authors:  Je-Hwan Lee; Stefan Faderl; John M Pagel; Chul Won Jung; Sung-Soo Yoon; Animesh D Pardanani; Pamela S Becker; Howard Lee; Jeongeun Choi; Kyoungjune Lee; Minkyoung Kim; Jorge E Cortes
Journal:  Blood Adv       Date:  2020-05-12
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.