| Literature DB >> 23333775 |
Armando Martinez-Guarneros1, Nalin Rastogi, David Couvin, Alejandro Escobar-Gutierrez, Livia Maria Gonçalves Rossi, Carlos A Vazquez-Chacon, Sandra Rivera-Gutierrez, Daniela Lozano, Arely Vergara-Castañeda, Jorge A Gonzalez-Y-Merchand, Gilberto Vaughan.
Abstract
Tuberculosis is an important public health problem in Mexico. However, limited information about the genetic diversity of Mycobacterium tuberculosis strains circulating in the country is available. In this work, 109 multidrug-resistant (MDR) M. tuberculosis isolates collected in 23 different states of Mexico in 2003 were retrospectively characterized by spoligotyping and MIRU-VNTRs. All isolates, except for a single cluster containing two strains (subcluster E1), were split when information from the 12-loci MIRUs and spoligo-pattern was simultaneously analyzed. The discriminative power of 12-loci MIRU-VNTR and spoligotyping, by the Hunter-Gaston index, were 0.9998 and 0.9011, respectively. These findings suggest that almost all cases were epidemiologically unrelated. Instead, the genetic variations observed among these strains are suggestive of emergence of acquired drug-resistance during the course of treatment. The results suggest a high degree of genetic variability and a high frequency of SIT53 (T1 family) spoligotype among the MDR M. tuberculosis isolates included in the study. Published by Elsevier B.V.Entities:
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Year: 2013 PMID： 23333775 DOI： 10.1016/j.meegid.2012.12.024
Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342