BACKGROUND: We conducted a cohort study to determine if proteinuria predicts cancer-related mortality in type 2 diabetic subjects. METHODS: Between July 1996 and June 2003, we enrolled 646 type 2 diabetic subjects. Participants were followed-up until December 31, 2008. The vital status was ascertained by linking records with computerized death certificates in Taiwan. RESULTS: During a median follow-up of 10.4 years, 158 subjects had died, including 59 from cancers. Subjects with proteinuria had a hazard ratio (HR) of 2.77 (95% CI 1.82-4.21) for all-cause mortality and 1.99 (95% CI 1.00-3.94) for cancer-related mortality after adjustment for demographic factors and medical conditions. Specifically, proteinuria showed a trend of increased colon cancer death. The presence of proteinuria significantly improved the predictive ability of cancer-related mortality (increase in concordance statistics or area under the ROC curve=0.03). Patients with both proteinuria and estimated glomerular filtration rate <60 ml/min per 1.73 m² showed higher HR for all-cause mortality than patients with proteinuria only (adjusted HRs (95% CI), 4.01 (2.42-6.67) vs. 2.69 (1.51-4.79), both p<0.01). CONCLUSIONS: Proteinuria can predict 10-year all-cause and cancer-related mortalities independently in type 2 diabetic subjects, over and above the established risk factors associated with type 2 diabetes.
BACKGROUND: We conducted a cohort study to determine if proteinuria predicts cancer-related mortality in type 2 diabetic subjects. METHODS: Between July 1996 and June 2003, we enrolled 646 type 2 diabetic subjects. Participants were followed-up until December 31, 2008. The vital status was ascertained by linking records with computerized death certificates in Taiwan. RESULTS: During a median follow-up of 10.4 years, 158 subjects had died, including 59 from cancers. Subjects with proteinuria had a hazard ratio (HR) of 2.77 (95% CI 1.82-4.21) for all-cause mortality and 1.99 (95% CI 1.00-3.94) for cancer-related mortality after adjustment for demographic factors and medical conditions. Specifically, proteinuria showed a trend of increased colon cancer death. The presence of proteinuria significantly improved the predictive ability of cancer-related mortality (increase in concordance statistics or area under the ROC curve=0.03). Patients with both proteinuria and estimated glomerular filtration rate <60 ml/min per 1.73 m² showed higher HR for all-cause mortality than patients with proteinuria only (adjusted HRs (95% CI), 4.01 (2.42-6.67) vs. 2.69 (1.51-4.79), both p<0.01). CONCLUSIONS:Proteinuria can predict 10-year all-cause and cancer-related mortalities independently in type 2 diabetic subjects, over and above the established risk factors associated with type 2 diabetes.
Authors: Yejin Mok; Shoshana H Ballew; Yingying Sang; Josef Coresh; Corinne E Joshu; Elizabeth A Platz; Kunihiro Matsushita Journal: Am J Epidemiol Date: 2021-05-04 Impact factor: 4.897
Authors: Kamel Mohammedi; Stephen Harrap; Giuseppe Mancia; Michel Marre; Neil Poulter; John Chalmers; Mark Woodward Journal: Cardiovasc Diabetol Date: 2021-01-04 Impact factor: 9.951
Authors: Dorothy A Rhoades; John Farley; Stephen M Schwartz; Kimberly M Malloy; Wenyu Wang; Lyle G Best; Ying Zhang; Tauqeer Ali; Fawn Yeh; Everett R Rhoades; Elisa Lee; Barbara V Howard Journal: Cancer Epidemiol Date: 2021-07-19 Impact factor: 2.890