| Literature DB >> 23333653 |
Thomas Gronemeyer1, Sebastian Wiese, Sören Grinhagens, Lukas Schollenberger, Ari Satyagraha, Lukas A Huber, Helmut E Meyer, Bettina Warscheid, Wilhelm W Just.
Abstract
A proteomics screen was initiated to identify Rab proteins regulating transport to and away from peroxisomes. Mass spectrometry-based protein correlation profiling of rat liver organelles and immunofluorescence analysis of the peroxisome candidate Rab proteins revealed Rab6, Rab10, Rab14 and Rab18 to associate with the peroxisomal membrane. While Rab14 localized to peroxisomes predominantly in its dominant-active form, other Rab proteins associated with peroxisomes in both their GTP- and GDP-bound state. In summary, our data suggest that Rab6, Rab10, Rab14 and Rab18 associate with the peroxisomal compartment and similar as previously shown for Rab8, Rab18 in its GDP-bound state favors peroxisome proliferation.Entities:
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Year: 2013 PMID： 23333653 DOI： 10.1016/j.febslet.2012.12.025
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124