Literature DB >> 23331174

14-Membered macrocyclic ring-derived toolbox: the identification of small molecule inhibitors of angiogenesis and early embryo development in zebrafish assay.

Madhu Aeluri1, Chinmoy Pramanik, Lakshindra Chetia, Naveen Kumar Mallurwar, Sridhar Balasubramanian, Gayathri Chandrasekar, Satish Srinivas Kitambi, Prabhat Arya.   

Abstract

A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was identified as an antiangiogenesis agent.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23331174     DOI： 10.1021/ol3032126

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay.

Authors:  Shiva Krishna Reddy Guduru; Srinivas Chamakuri; Gayathri Chandrasekar; Satish Srinivas Kitambi; Prabhat Arya
Journal:  ACS Med Chem Lett       Date:  2013-05-24       Impact factor: 4.345

2.  Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.

Authors:  Amanda J Welford; John J Caldwell; Manjuan Liu; Meirion Richards; Nathan Brown; Cara Lomas; Graham J Tizzard; Mateusz B Pitak; Simon J Coles; Suzanne A Eccles; Florence I Raynaud; Ian Collins
Journal:  Chemistry       Date:  2016-03-01       Impact factor: 5.236

Review 3.  Diversity-oriented synthetic strategies applied to cancer chemical biology and drug discovery.

Authors:  Ian Collins; Alan M Jones
Journal:  Molecules       Date:  2014-10-27       Impact factor: 4.411

4.  Modular Synthesis of Diverse Natural Product-Like Macrocycles: Discovery of Hits with Antimycobacterial Activity.

Authors:  Mark Dow; Francesco Marchetti; Katherine A Abrahams; Luis Vaz; Gurdyal S Besra; Stuart Warriner; Adam Nelson
Journal:  Chemistry       Date:  2017-05-02       Impact factor: 5.236
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.