BACKGROUND: Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing. MAIN OBSERVATION: We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared. CONCLUSIONS: During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.
BACKGROUND:Granulomatous slack skin is a very rare subtype of T-cell cutaneous lymphoma, characterized by the slow development of cutaneous sagging, especially on flexural areas. Its behavior is indolent and the treatment, in the majority of cases, disappointing. MAIN OBSERVATION: We report a 54-year-old black patient with granulomatous slack skin, who at the beginning of the investigation showed intense xeroderma and generalized lymph node enlargement. The diagnosis was established based on histopathologic findings long before the disease's characteristic clinical presentation appeared. CONCLUSIONS: During the twelve years of follow-up, the clinical manifestation evolved to marked skin looseness, most predominant in flexural regions, illustrating the clinical hallmark of granulomatous slack skin, long after first histological abnormalities were observed.
Authors: Günter Burg; Werner Kempf; Antonio Cozzio; Josef Feit; Rein Willemze; Elaine S Jaffe; Reinhard Dummer; Emilio Berti; Lorenzo Cerroni; Sergio Chimenti; José L Diaz-Perez; Florent Grange; Nancy L Harris; Dmitry V Kazakov; Helmut Kerl; Michael Kurrer; Robert Knobler; Chris J L M Meijer; Nicola Pimpinelli; Elisabeth Ralfkiaer; Robin Russell-Jones; Christian Sander; Marco Santucci; Wolfram Sterry; Steven H Swerdlow; Maarten H Vermeer; Janine Wechsler; Sean Whittaker Journal: J Cutan Pathol Date: 2005-11 Impact factor: 1.587
Authors: Rein Willemze; Elaine S Jaffe; Günter Burg; Lorenzo Cerroni; Emilio Berti; Steven H Swerdlow; Elisabeth Ralfkiaer; Sergio Chimenti; José L Diaz-Perez; Lyn M Duncan; Florent Grange; Nancy Lee Harris; Werner Kempf; Helmut Kerl; Michael Kurrer; Robert Knobler; Nicola Pimpinelli; Christian Sander; Marco Santucci; Wolfram Sterry; Maarten H Vermeer; Janine Wechsler; Sean Whittaker; Chris J L M Meijer Journal: Blood Date: 2005-02-03 Impact factor: 22.113
Authors: Werner Kempf; Sonja Ostheeren-Michaelis; Marco Paulli; Marco Lucioni; Janine Wechsler; Heike Audring; Chalid Assaf; Thomas Rüdiger; Rein Willemze; Chris J L M Meijer; Emilio Berti; Lorenzo Cerroni; Marco Santucci; Christian Hallermann; Mark Berneburg; Sergio Chimenti; Alistair Robson; Martà Marschalko; Dmitry V Kazakov; Tony Petrella; Sylvie Fraitag; Agnes Carlotti; Philippe Courville; Hubert Laeng; Robert Knobler; Philippa Golling; Reinhard Dummer; Günter Burg Journal: Arch Dermatol Date: 2008-12
Authors: Maria Isabel Beatriz Lim Puno; Ma Teresa Ela Dimagiba; Ma Jasmin Jacinto Jamora; Filomena Legarda Montinola; Patricia Ty Tinio Journal: JAAD Case Rep Date: 2017-07-16