Literature DB >> 23328974

Immunomodulation and the quorum sensing molecule 3-oxo-C12-homoserine lactone: the importance of chemical scaffolding for probe development.

Amanda L Garner1, Jing Yu, Anjali K Struss, Gunnar F Kaufmann, Vladimir V Kravchenko, Kim D Janda.   

Abstract

As a guide for chemical probe design, focused analogue synthetic studies were undertaken upon the lactone ring of 3-oxo-C(12)-homoserine lactone. We have concluded that hydrolytic instability of the heterocyclic ring is pivotal for its ability to modulate immune signaling and probe preparation was aligned with these findings.

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Year:  2013        PMID： 23328974      PMCID： PMC3566768          DOI： 10.1039/c3cc38851d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  29 in total

Review 1.  Innate immune recognition.

Authors:  Charles A Janeway; Ruslan Medzhitov
Journal:  Annu Rev Immunol       Date:  2001-10-04       Impact factor: 28.527

Review 2.  Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist.

Authors:  J B Lyczak; C L Cannon; G B Pier
Journal:  Microbes Infect       Date:  2000-07       Impact factor: 2.700

Review 3.  Listening in on bacteria: acyl-homoserine lactone signalling.

Authors:  Clay Fuqua; E Peter Greenberg
Journal:  Nat Rev Mol Cell Biol       Date:  2002-09       Impact factor: 94.444

4.  The Pseudomonas aeruginosa autoinducer N-3-oxododecanoyl homoserine lactone accelerates apoptosis in macrophages and neutrophils.

Authors:  Kazuhiro Tateda; Yoshikazu Ishii; Manabu Horikawa; Tetsuya Matsumoto; Shinichi Miyairi; Jean Claude Pechere; Theodore J Standiford; Masaji Ishiguro; Keizo Yamaguchi
Journal:  Infect Immun       Date:  2003-10       Impact factor: 3.441

Review 5.  Innate immune responses to Pseudomonas aeruginosa infection.

Authors:  Elise G Lavoie; Tamding Wangdi; Barbara I Kazmierczak
Journal:  Microbes Infect       Date:  2011-08-02       Impact factor: 2.700

6.  The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo.

Authors:  Roger S Smith; Sarah G Harris; Richard Phipps; Barbara Iglewski
Journal:  J Bacteriol       Date:  2002-02       Impact factor: 3.490

7.  Modification of in vivo and in vitro T- and B-cell-mediated immune responses by the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone.

Authors:  Adam J Ritchie; Andrew O W Yam; Kara M Tanabe; Scott A Rice; Margaret A Cooley
Journal:  Infect Immun       Date:  2003-08       Impact factor: 3.441

8.  Pseudomonas aeruginosa autoinducer enters and functions in mammalian cells.

Authors:  Simon C Williams; Erin K Patterson; Nancy L Carty; John A Griswold; Abdul N Hamood; Kendra P Rumbaugh
Journal:  J Bacteriol       Date:  2004-04       Impact factor: 3.490

9.  Synthetic analogues of the bacterial signal (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators.

Authors:  Siri Ram Chhabra; Chris Harty; Doreen S W Hooi; Mavis Daykin; Paul Williams; Gary Telford; David I Pritchard; Barrie W Bycroft
Journal:  J Med Chem       Date:  2003-01-02       Impact factor: 7.446

Review 10.  Lung infections associated with cystic fibrosis.

Authors:  Jeffrey B Lyczak; Carolyn L Cannon; Gerald B Pier
Journal:  Clin Microbiol Rev       Date:  2002-04       Impact factor: 26.132
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  1 in total

1.  Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones.

Authors:  Josep Rayo; Rachel Gregor; Nicholas T Jacob; Rambabu Dandela; Luba Dubinsky; Alex Yashkin; Alexander Aranovich; Manikandan Thangaraj; Orna Ernst; Eran Barash; Sergey Malitsky; Bogdan I Florea; Bastiaan P Krom; Erik A C Wiemer; Valerie A Kickhoefer; Leonard H Rome; John C Mathison; Gunnar F Kaufmann; Herman S Overkleeft; Benjamin F Cravatt; Tsaffrir Zor; Kim D Janda; Richard J Ulevitch; Vladimir V Kravchenko; Michael M Meijler
Journal:  Proc Natl Acad Sci U S A       Date:  2021-03-23       Impact factor: 12.779
  1 in total

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