Jonathan Hogan1, Gerald B Appel. 1. Division of Nephrology, Department of Medicine, Columbia University Medical Center, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: Lupus nephritis occurs in as many as half of patients presenting with systemic lupus erythematosus and is a major predictor of morbidity and mortality in this patient population. Prior to the last decade, the treatment of lupus nephritis was largely limited to corticosteroids, high-dose alkylating agents, and azathioprine, and this therapy was broadly prescribed regardless of patient demographics, clinical presentation, or prior toxicities. RECENT FINDINGS: Over the last decade, new immunomodulatory agents have emerged as effective induction and maintenance therapies in lupus nephritis. With these options, physicians are able to individualize the treatment regimens in an attempt to maximize clinical benefit and minimize adverse events. Moreover, the influence of patient demographics on disease severity and response to treatment has come to the forefront. SUMMARY: Here, we review the recent progress made in the therapy of lupus nephritis with a focus on the randomized controlled trials which have demonstrated the efficacy of these new treatment regimens.
PURPOSE OF REVIEW: Lupus nephritis occurs in as many as half of patients presenting with systemic lupus erythematosus and is a major predictor of morbidity and mortality in this patient population. Prior to the last decade, the treatment of lupus nephritis was largely limited to corticosteroids, high-dose alkylating agents, and azathioprine, and this therapy was broadly prescribed regardless of patient demographics, clinical presentation, or prior toxicities. RECENT FINDINGS: Over the last decade, new immunomodulatory agents have emerged as effective induction and maintenance therapies in lupus nephritis. With these options, physicians are able to individualize the treatment regimens in an attempt to maximize clinical benefit and minimize adverse events. Moreover, the influence of patient demographics on disease severity and response to treatment has come to the forefront. SUMMARY: Here, we review the recent progress made in the therapy of lupus nephritis with a focus on the randomized controlled trials which have demonstrated the efficacy of these new treatment regimens.
Authors: Hege L Pedersen; Kjersti D Horvei; Dhivya Thiyagarajan; Gudrun E Norby; Natalya Seredkina; Gabriella Moroni; Gro Ø Eilertsen; Hallvard Holdaas; Erik H Strøm; Gunnstein Bakland; Pier-Luigi Meroni; Ole P Rekvig Journal: J Pathol Clin Res Date: 2018-04-06