Literature DB >> 23327640

Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).

Min Hye Yang1, Young-Won Chin, Kee Dong Yoon, Jinwoong Kim.   

Abstract

Abstract Twenty-three phenolic compounds were isolated from Dioscorea opposita by bioactivity-guided method and their inhibitory effect against pancreatic lipase was evaluated. A total of 15 isolates reduced lipase activity at IC50 values of less than 50 µM and 3,3',5-trihydroxy-2'-methoxybibenzyl showed the highest inhibition with an IC50 value of 8.8 µM. This study is a first to reveal the pancreatic lipase inhibitory activity by both D. opposita and its isolated compounds.

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Year:  2013        PMID： 23327640     DOI： 10.3109/14756366.2012.742517

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  9 in total

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  9 in total

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