| Literature DB >> 23327616 |
U Bin Kim1, Daniel P Furkert, Margaret A Brimble.
Abstract
The first total synthesis of the monoamine oxidase inhibitors chaetoquadrins A-C has been accomplished. Key steps in the synthesis include an aromatic Claisen rearrangement, asymmetric boron aldol reaction and acid-mediated spiroketalization. Comparison of spectral data for the synthetic spiroketals confirmed the proposed structure for these natural products.Entities:
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Year: 2013 PMID： 23327616 DOI： 10.1021/ol303482k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005