| Literature DB >> 23327495 |
Emma E Nagy1, I F Dempsey Hyatt, Kristen E Gettys, Shawn T Yeazell, Stephen K Frempong, Mitchell P Croatt.
Abstract
A step-economical synthesis of clinprost is reported that concludes with 3 different transition metal-catalyzed reactions: Pd-catalyzed decarboxylation with allylic rearrangement, Rh-catalyzed diene-ene [2+2+1] reaction, and Ru-catalyzed cross-metathesis reaction. The complexity bestowed to the molecule from these reactions converts a readily accessible ester to clinprost without using protecting groups in only 9 total steps.Entities:
Year: 2013 PMID： 23327495 DOI： 10.1021/ol303402e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005