OBJECTIVE: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. STUDY DESIGN: From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. RESULTS: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. CONCLUSION: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
OBJECTIVE: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. STUDY DESIGN: From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. RESULTS: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. CONCLUSION: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
Authors: Rosiane Aparecida Miranda; Claudinéia Conationi da Silva Franco; Júlio Cezar de Oliveira; Luiz Felipe Barella; Laize Peron Tófolo; Tatiane Aparecida Ribeiro; Audrei Pavanello; Ellen Paula Santos da Conceição; Rosana Torrezan; James Armitage; Patrícia Cristina Lisboa; Egberto Gaspar de Moura; Paulo Cezar de Freitas Mathias; Elaine Vieira Journal: Endocrine Date: 2016-04-26 Impact factor: 3.633
Authors: Young-Ah You; Ji Hye Lee; Eun Jin Kwon; Jae Young Yoo; Woo-Sung Kwon; Myung-Geol Pang; Young Ju Kim Journal: Mol Cell Proteomics Date: 2015-09-04 Impact factor: 5.911