Literature DB >> 233257

Mechanism of beta-adrenergic relaxation of smooth muscle.

C R Scheid, T W Honeyman, F S Fay.   

Abstract

The mechanism of beta-adrenergic relaxation was investigated in isolated smooth muscle cells. Beta-adrenergic agents stimulate cyclic AMP-dependent phosphorylation, enhance Na+/K+ transport and induce relaxation. The stimulation of Na+/K+ transport is obligatory for relaxation, and we suggest that this stimulation induces relaxation through enhanced Na+/Ca2+ exchange.

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Year:  1979        PMID： 233257     DOI： 10.1038/277032a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  53 in total

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Authors:  D Reinhardt
Journal:  Eur J Pediatr       Date:  1989-01       Impact factor: 3.183

2.  Sites of interactions of surfactants with beta-adrenergic responses in trout (Salmo gairdneri) gills.

Authors:  R M Stagg; T J Shuttleworth
Journal:  J Comp Physiol B       Date:  1987       Impact factor: 2.200

3.  Identification and characterization of major ionic currents in isolated smooth muscle cells using the voltage-clamp technique.

Authors:  J V Walsh; J J Singer
Journal:  Pflugers Arch       Date:  1987-02       Impact factor: 3.657

4.  Stimulation of sodium pump by vasoactive intestinal peptide in guinea-pig isolated trachea: potential contribution to mechanisms underlying relaxation of smooth muscle.

Authors:  K J Morrison; P M Vanhoutte
Journal:  Br J Pharmacol       Date:  1996-06       Impact factor: 8.739

Review 5.  Modulation of calcium sensitivity in guinea pig taenia coli: skinned fiber studies.

Authors:  J C Rüegg; G Pfitzer
Journal:  Experientia       Date:  1985-08-15

6.  Effects of relaxants on electrical and mechanical activities in the guinea-pig tracheal muscle.

Authors:  K Honda; T Satake; K Takagi; T Tomita
Journal:  Br J Pharmacol       Date:  1986-04       Impact factor: 8.739

7.  Effects of a water-soluble forskolin derivative (NKH477) and a membrane-permeable cyclic AMP analogue on noradrenaline-induced Ca2+ mobilization in smooth muscle of rabbit mesenteric artery.

Authors:  S Ito; S Suzuki; T Itoh
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

8.  Bronchodilator-mediated relaxation of normal and ovalbumin-sensitized guinea-pig airways: lack of correlation with lung adenylate cyclase activation.

Authors:  J F Burka; M H Saad
Journal:  Br J Pharmacol       Date:  1984-11       Impact factor: 8.739

9.  Dependence of cyclic-AMP induced relaxation on Ca2+ and calmodulin in skinned smooth muscle of guinea pig Taenia coli.

Authors:  K D Meisheri; J C Ruegg
Journal:  Pflugers Arch       Date:  1983-12       Impact factor: 3.657

10.  Formoterol, fenoterol, and salbutamol as partial agonists for relaxation of maximally contracted guinea pig tracheae: comparison of relaxation with receptor binding.

Authors:  H Lemoine; C Overlack; A Köhl; H Worth; D Reinhardt
Journal:  Lung       Date:  1992       Impact factor: 2.584
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