BACKGROUND: Ambient fine-particle particulate matter (PM2.5) exposure is associated with the decline in pulmonary function, prevalence of coronary heart disease and incidence of myocardial infarction. The study is to observe the effects of ambient PM2.5 on the cardiovascular system and to explore the potential inflammatory and immune mechanisms. METHODS: The subjects included 110 traffic policemen in Shanghai, China, who were aged 25-55 years. Two-times continuous 24 h individual-level PM2.5 measurements were performed in winter and summer, respectively. The inflammatory marker (high-sensitivity C-reactive protein, hs-CRP), immune parameters (IgA, IgG, IgM and IgE) and lymphocyte profiles (CD4 T cells, CD8 T cells, CD4/CD8 T cells) were measured in blood. The associations between individual-level PM2.5 and inflammatory marker and immune parameters were analysed by multiple linear regression. RESULTS: The average concentration of 24 h personal PM2.5 for participants was 116.98 μg/m(3) and 86.48 μg/m(3) in winter and summer, respectively. In the main analysis, PM2.5 exposure is associated with the increases in hs-CRP of 1.1%, IgG of 6.7%, IgM of 11.2% and IgE of 3.3% in participants, and decreases in IgA of 4.7% and CD8 of 0.7%, whereas we found no statistical association in CD4 T cells and CD4/CD8 T cells. In the adjusted model, the results showed that the increase of PM2.5 was associated with the changes of inflammatory markers and immune markers both in winter and summer. CONCLUSIONS: Traffic policeman have been a high-risk group suffering inflammatory response or immune injury because of the high exposure to PM2.5. These findings provided new insight into the mechanisms linking ambient PM2.5 and inflammatory and immune response.
BACKGROUND: Ambient fine-particle particulate matter (PM2.5) exposure is associated with the decline in pulmonary function, prevalence of coronary heart disease and incidence of myocardial infarction. The study is to observe the effects of ambient PM2.5 on the cardiovascular system and to explore the potential inflammatory and immune mechanisms. METHODS: The subjects included 110 traffic policemen in Shanghai, China, who were aged 25-55 years. Two-times continuous 24 h individual-level PM2.5 measurements were performed in winter and summer, respectively. The inflammatory marker (high-sensitivity C-reactive protein, hs-CRP), immune parameters (IgA, IgG, IgM and IgE) and lymphocyte profiles (CD4 T cells, CD8 T cells, CD4/CD8 T cells) were measured in blood. The associations between individual-level PM2.5 and inflammatory marker and immune parameters were analysed by multiple linear regression. RESULTS: The average concentration of 24 h personal PM2.5 for participants was 116.98 μg/m(3) and 86.48 μg/m(3) in winter and summer, respectively. In the main analysis, PM2.5 exposure is associated with the increases in hs-CRP of 1.1%, IgG of 6.7%, IgM of 11.2% and IgE of 3.3% in participants, and decreases in IgA of 4.7% and CD8 of 0.7%, whereas we found no statistical association in CD4 T cells and CD4/CD8 T cells. In the adjusted model, the results showed that the increase of PM2.5 was associated with the changes of inflammatory markers and immune markers both in winter and summer. CONCLUSIONS: Traffic policeman have been a high-risk group suffering inflammatory response or immune injury because of the high exposure to PM2.5. These findings provided new insight into the mechanisms linking ambient PM2.5 and inflammatory and immune response.
Authors: Sadie Costello; Michael D Attfield; Jay H Lubin; Andreas M Neophytou; Aaron Blair; Daniel M Brown; Patricia A Stewart; Roel Vermeulen; Ellen A Eisen; Debra T Silverman Journal: Am J Epidemiol Date: 2018-12-01 Impact factor: 4.897
Authors: Xuejiao Zeng; Jie Liu; Xihao Du; Jia Zhang; Kun Pan; Wei Shan; Yuquan Xie; Weimin Song; Jinzhuo Zhao Journal: Environ Sci Pollut Res Int Date: 2018-05-26 Impact factor: 4.223
Authors: Jason Y Y Wong; Bryan A Bassig; Wei Hu; Wei Jie Seow; Meredith S Shiels; Bu-Tian Ji; George S Downward; Yunchao Huang; Kaiyun Yang; Jihua Li; Jun He; Ying Chen; Allan Hildesheim; Roel Vermeulen; Qing Lan; Nathaniel Rothman Journal: J Toxicol Environ Health A Date: 2019-05-13
Authors: Sandra Pirela; Ramon Molina; Christa Watson; Joel M Cohen; Dhimiter Bello; Philip Demokritou; Joseph Brain Journal: Inhal Toxicol Date: 2013-07-29 Impact factor: 2.724
Authors: Peter E Umukoro; Jason Y Y Wong; Jennifer M Cavallari; Shona C Fang; Chensheng Lu; Xihong Lin; Murray A Mittleman; Georg Schmidt; David C Christiani Journal: J Occup Environ Med Date: 2016-03 Impact factor: 2.162