BACKGROUND: There are limited data supporting an association between retinal microvascular changes and cardiovascular mortality, but there is no convincing evidence of an independent or direct association with atherosclerosis in coronary artery disease (CAD) patients. The present study examines the relationship between retinal microvascular changes and angiographic findings. METHODS: Patients who were candidates for angiography were, at first, referred to the ophthalmology department for the determination of the severity of retinal atherosclerosis based on the Scheie classification. Angiography was carried out afterwards. Each patient completed a questionnaire, also providing information on risk factors. For each patient, the Gensini score was calculated using angiography findings. RESULTS: A total of 168 patients (99 males and 69 females) with a mean age of 55.3±11.9 years were included in this study. The results show a significant association between CAD severity and retinal artery atherosclerosis (r = 0.47, p = 0.0001). In multiple regression analyses with CAD severity (using Gensini scoring) as a dependent variable, we observed a significant association between atherosclerosis scores based on Scheie criteria (β=0.31, p<0.0001), diabetes mellitus (DM) (β=0.29, p<0.0001), hypertension (β=0.23, p<0.0001), smoking (β=0.20, p<0.0001), and age (β=0.15, p<0.0001). CONCLUSIONS: The results demonstrate that fundoscopic changes might be a predictor of CADs. However, more well-designed studies to verify these results are still needed.
BACKGROUND: There are limited data supporting an association between retinal microvascular changes and cardiovascular mortality, but there is no convincing evidence of an independent or direct association with atherosclerosis in coronary artery disease (CAD) patients. The present study examines the relationship between retinal microvascular changes and angiographic findings. METHODS:Patients who were candidates for angiography were, at first, referred to the ophthalmology department for the determination of the severity of retinal atherosclerosis based on the Scheie classification. Angiography was carried out afterwards. Each patient completed a questionnaire, also providing information on risk factors. For each patient, the Gensini score was calculated using angiography findings. RESULTS: A total of 168 patients (99 males and 69 females) with a mean age of 55.3±11.9 years were included in this study. The results show a significant association between CAD severity and retinal artery atherosclerosis (r = 0.47, p = 0.0001). In multiple regression analyses with CAD severity (using Gensini scoring) as a dependent variable, we observed a significant association between atherosclerosis scores based on Scheie criteria (β=0.31, p<0.0001), diabetes mellitus (DM) (β=0.29, p<0.0001), hypertension (β=0.23, p<0.0001), smoking (β=0.20, p<0.0001), and age (β=0.15, p<0.0001). CONCLUSIONS: The results demonstrate that fundoscopic changes might be a predictor of CADs. However, more well-designed studies to verify these results are still needed.
Authors: Alexander Pinhas; Moataz Razeen; Michael Dubow; Alexander Gan; Toco Y Chui; Nishit Shah; Mitul Mehta; Ronald C Gentile; Rishard Weitz; Joseph B Walsh; Yusufu N Sulai; Joseph Carroll; Alfredo Dubra; Richard B Rosen Journal: Invest Ophthalmol Vis Sci Date: 2014-11-20 Impact factor: 4.799
Authors: Kevin Phan; Paul Mitchell; Gerald Liew; Adam J Plant; Sarah B Wang; Joshua Xu; Joseph Chiha; Aravinda Thiagalingam; George Burlutsky; Bamini Gopinath Journal: J Thorac Dis Date: 2016-07 Impact factor: 2.895
Authors: Bo Lun Xu; Wen Li Zhou; Tie Pei Zhu; Ke Yun Cheng; Yi Jie Li; Hai Jing Zhan; Li Gang Jiang; Yu Hua Tong Journal: Sci Rep Date: 2019-07-29 Impact factor: 4.379
Authors: Pikkel Josef; Ibrahim Ali; Prober Ariel; Marmor Alon; Assy Nimer Journal: Int J Environ Res Public Health Date: 2013-08-06 Impact factor: 3.390