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Literature DB >> 23322269

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

Qingzhi Zhang¹, Agnieszka Kulczynska, David J Webb, Ian L Megson, Nigel P Botting.

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of γ-glutamyl transpeptidase (γ-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 23322269 PMCID： PMC3785133 DOI： 10.1039/c2cc38382a

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

23 in total

1. N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors.

Authors: M Xian; X Li; X Tang; X Chen; Z Zheng; J J Galligan; D L Kreulen; P G Wang
Journal: Bioorg Med Chem Lett Date: 2001-09-03 Impact factor: 2.823

2. Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial.

Authors: Tiziana Bove; Giovanni Landoni; Maria Grazia Calabrò; Giacomo Aletti; Giovanni Marino; Elisa Cerchierini; Giuseppe Crescenzi; Alberto Zangrillo
Journal: Circulation Date: 2005-06-21 Impact factor: 29.690

Review 3. "Renal-dose" dopamine for the treatment of acute renal failure: scientific rationale, experimental studies and clinical trials.

Authors: M D Denton; G M Chertow; H R Brady
Journal: Kidney Int Date: 1996-07 Impact factor: 10.612

4. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.

Authors: Noriyuki Miyata; Takayuki Seki; Yu Tanaka; Tomohiro Omura; Kazuo Taniguchi; Mariko Doi; Kagumi Bandou; Shunichi Kametani; Masakazu Sato; Shigeru Okuyama; Liana Cambj-Sapunar; David R Harder; Richard J Roman
Journal: J Pharmacol Exp Ther Date: 2005-04-14 Impact factor: 4.030

Review 5. Acute kidney injury: a relevant complication after cardiac surgery.

Authors: Giovanni Mariscalco; Roberto Lorusso; Carmelo Dominici; Attilio Renzulli; Andrea Sala
Journal: Ann Thorac Surg Date: 2011-08-27 Impact factor: 4.330

6. The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

Authors: Dennis Schade; Joscha Kotthaus; Helen Hungeling; Jürke Kotthaus; Bernd Clement
Journal: ChemMedChem Date: 2009-10 Impact factor: 3.466

Review 7. Ischaemia-reperfusion injury.

Authors: P A Grace
Journal: Br J Surg Date: 1994-05 Impact factor: 6.939

Review 8. Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities.

Authors: Michelle Le Brocq; Stephen J Leslie; Philip Milliken; Ian L Megson
Journal: Antioxid Redox Signal Date: 2008-09 Impact factor: 8.401

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation.

1. N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors.

2. Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial.

Review 3. "Renal-dose" dopamine for the treatment of acute renal failure: scientific rationale, experimental studies and clinical trials.

4. Beneficial effects of a new 20-hydroxyeicosatetraenoic acid synthesis inhibitor, TS-011 [N-(3-chloro-4-morpholin-4-yl) phenyl-N'-hydroxyimido formamide], on hemorrhagic and ischemic stroke.

Review 5. Acute kidney injury: a relevant complication after cardiac surgery.

6. The peptidylglycine alpha-amidating monooxygenase (PAM): a novel prodrug strategy for amidoximes and N-hydroxyguanidines?

Review 7. Ischaemia-reperfusion injury.

Review 8. Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities.

9. Metabolism and vascular effects of gamma-L-glutamyl-L-dopa on the isolated rat kidney.

10. Reaction of NO with O2-. implications for the action of endothelium-derived relaxing factor (EDRF).

Review 1. Glutathione S-conjugates as prodrugs to target drug-resistant tumors.

Review 2. Nanoparticulation of Prodrug into Medicines for Cancer Therapy.