Literature DB >> 23321551

Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes.

Donald M Bers1, Thomas R Shannon.   

Abstract

Sarcoplasmic reticulum (SR) Ca content ([Ca]SRT) is critical to both normal cardiac function and electrophysiology, and changes associated with pathology contribute to systolic and diastolic dysfunction and arrhythmias. The intra-SR free [Ca] ([Ca]SR) dictates the [Ca]SRT, the driving force for Ca release and regulates release channel gating. We discuss measurement of [Ca]SR and [Ca]SRT, how [Ca]SR regulates activation and termination of release, and how Ca diffuses within the SR and influences SR Ca release during excitation-contraction coupling, Ca sparks and Cac waves. The entire SR network is connected and its lumen is also continuous with the nuclear envelope. Rapid Ca diffusion within the SR could stabilize and balance local [Ca]SR within the myocyte, but restrictions to diffusion can create spatial inhomogeneities. Experimental measurements and mathematical models of [Ca]SR to date have greatly enriched our understanding of these [Ca]SR dynamics, but controversies exist and may stimulate new measurements and analysis.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23321551      PMCID： PMC3628081          DOI： 10.1016/j.yjmcc.2013.01.002

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  47 in total

1.  Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve.

Authors:  Thomas R Shannon; Tao Guo; Donald M Bers
Journal:  Circ Res       Date:  2003-06-05       Impact factor: 17.367

2.  Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release.

Authors:  Eric A Sobie; Keith W Dilly; Jader dos Santos Cruz; W Jonathan Lederer; M Saleet Jafri
Journal:  Biophys J       Date:  2002-07       Impact factor: 4.033

3.  Quantitative assessment of the SR Ca2+ leak-load relationship.

Authors:  Thomas R Shannon; Kenneth S Ginsburg; Donald M Bers
Journal:  Circ Res       Date:  2002-10-04       Impact factor: 17.367

4.  Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytes.

Authors:  Dmitry Terentyev; Serge Viatchenko-Karpinski; Héctor H Valdivia; Ariel L Escobar; Sandor Györke
Journal:  Circ Res       Date:  2002-09-06       Impact factor: 17.367

5.  Theoretical study of L-type Ca(2+) current inactivation kinetics during action potential repolarization and early afterdepolarizations.

Authors:  Stefano Morotti; Eleonora Grandi; Aurora Summa; Kenneth S Ginsburg; Donald M Bers
Journal:  J Physiol       Date:  2012-05-14       Impact factor: 5.182

6.  Potentiation of fractional sarcoplasmic reticulum calcium release by total and free intra-sarcoplasmic reticulum calcium concentration.

Authors:  T R Shannon; K S Ginsburg; D M Bers
Journal:  Biophys J       Date:  2000-01       Impact factor: 4.033

7.  Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.

Authors:  Michael J Cutler; Xiaoping Wan; Bradley N Plummer; Haiyan Liu; Isabelle Deschenes; Kenneth R Laurita; Roger J Hajjar; David S Rosenbaum
Journal:  Circulation       Date:  2012-09-27       Impact factor: 29.690

8.  Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit.

Authors:  Johan Hake; Andrew G Edwards; Zeyun Yu; Peter M Kekenes-Huskey; Anushka P Michailova; J Andrew McCammon; Michael J Holst; Masahiko Hoshijima; Andrew D McCulloch
Journal:  J Physiol       Date:  2012-04-10       Impact factor: 5.182

9.  Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by luminal Ca2+.

Authors:  R Sitsapesan; A J Williams
Journal:  J Membr Biol       Date:  1994-02       Impact factor: 1.843

10.  Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes.

Authors:  Joshua T Maxwell; Lothar A Blatter
Journal:  J Physiol       Date:  2012-09-17       Impact factor: 5.182
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  23 in total

1.  Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.

Authors:  Daisuke Sato; Thomas R Shannon; Donald M Bers
Journal:  Biophys J       Date:  2016-01-19       Impact factor: 4.033

2.  The role of spatial organization of Ca2+ release sites in the generation of arrhythmogenic diastolic Ca2+ release in myocytes from failing hearts.

Authors:  Andriy E Belevych; Hsiang-Ting Ho; Ingrid M Bonilla; Radmila Terentyeva; Karsten E Schober; Dmitry Terentyev; Cynthia A Carnes; Sándor Györke
Journal:  Basic Res Cardiol       Date:  2017-06-13       Impact factor: 17.165

3.  Transitions of protein traffic from cardiac ER to junctional SR.

Authors:  Naama H Sleiman; Timothy P McFarland; Larry R Jones; Steven E Cala
Journal:  J Mol Cell Cardiol       Date:  2015-01-29       Impact factor: 5.000

4.  Cardiac alternans and ventricular fibrillation: a bad case of ryanodine receptors reneging on their duty.

Authors:  Ariel L Escobar; Héctor H Valdivia
Journal:  Circ Res       Date:  2014-04-25       Impact factor: 17.367

Review 5.  Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy.

Authors:  Chike C Nwabuo; Ramachandran S Vasan
Journal:  Curr Hypertens Rep       Date:  2020-02-03       Impact factor: 5.369

6.  Afterdepolarizations and abnormal calcium handling in atrial myocytes with modulated SERCA uptake: a sensitivity analysis of calcium handling channels.

Authors:  Andy C Y Lo; Jieyun Bai; Patrick A Gladding; Vadim V Fedorov; Jichao Zhao
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2020-05-25       Impact factor: 4.226

7.  The long and winding road home: how junctin and triadin find their way to the junctional SR.

Authors:  Benjamin M L Drum; Luis F Santana
Journal:  J Mol Cell Cardiol       Date:  2015-02-02       Impact factor: 5.000

8.  Optical Mapping of Intra-Sarcoplasmic Reticulum Ca2+ and Transmembrane Potential in the Langendorff-perfused Rabbit Heart.

Authors:  Lianguo Wang; Nicole M De Jesus; Crystal M Ripplinger
Journal:  J Vis Exp       Date:  2015-09-10       Impact factor: 1.355

9.  Role of the basement membrane in regulation of cardiac electrical properties.

Authors:  Huaxiao Yang; Thomas K Borg; Zhonghai Wang; Zhen Ma; Bruce Z Gao
Journal:  Ann Biomed Eng       Date:  2014-02-28       Impact factor: 3.934

10.  Activation and propagation of Ca2+ release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle.

Authors:  Tanya R Cully; Joshua N Edwards; Bradley S Launikonis
Journal:  J Physiol       Date:  2014-06-27       Impact factor: 5.182
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