BACKGROUND: Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9-11years at study commencement. METHODS: 8099 children (mean age 10.4years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later. RESULTS: Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13-3.34) and externalising (OR=1.97; 95% CI 1.19-3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs. CONCLUSIONS: Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology.
BACKGROUND: Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9-11years at study commencement. METHODS: 8099 children (mean age 10.4years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later. RESULTS: Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13-3.34) and externalising (OR=1.97; 95% CI 1.19-3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs. CONCLUSIONS: Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology.
Authors: Antonella Trotta; Louise Arseneault; Avshalom Caspi; Terrie E Moffitt; Andrea Danese; Carmine Pariante; Helen L Fisher Journal: Schizophr Bull Date: 2020-02-26 Impact factor: 9.306
Authors: Saliha El Bouhaddani; Lieke van Domburgh; Barbara Schaefer; Theo A H Doreleijers; Wim Veling Journal: Eur Child Adolesc Psychiatry Date: 2019-04-09 Impact factor: 4.785
Authors: Nicole R Karcher; Deanna M Barch; Shelli Avenevoli; Mark Savill; Rebekah S Huber; Tony J Simon; Ingrid N Leckliter; Kenneth J Sher; Rachel L Loewy Journal: JAMA Psychiatry Date: 2018-08-01 Impact factor: 21.596
Authors: Monica E Calkins; Tyler M Moore; Theodore D Satterthwaite; Daniel H Wolf; Bruce I Turetsky; David R Roalf; Kathleen R Merikangas; Kosha Ruparel; Christian G Kohler; Ruben C Gur; Raquel E Gur Journal: World Psychiatry Date: 2017-02 Impact factor: 49.548
Authors: Leon Fonville; Kathrin Cohen Kadosh; Mark Drakesmith; Anirban Dutt; Stanley Zammit; Josephine Mollon; Abraham Reichenberg; Glyn Lewis; Derek K Jones; Anthony S David Journal: Cereb Cortex Date: 2015-08-18 Impact factor: 5.357