Y Ni1, G Shi, H Wan. 1. Department of Pulmonary Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Abstract
OBJECTIVE: To assess the effect of cardioselective β-blockers on pulmonary function in patients with chronic obstructive pulmonary disease (COPD). METHODS: The Embase and MEDLINE™ databases and the Cochrane Controlled Trials Register were searched comprehensively to identify all relevant clinical trials in humans published between January 1966 and May 2011. Randomized, blinded, placebo-controlled trials that studied the effects of cardioselective β-blockers on the forced expiratory volume in 1 s (FEV(1)) and the responsiveness of the FEV(1) to β-agonist administration in patients with COPD were included in the analysis. RESULTS: Five studies were identified: four of these assessed both cardioselective and nonselective β-blockers; one assessed only cardioselective β-blockers. The FEV(1) was shown to decrease by 0.14 l with nonselective β-blockers and by 0.03 l with cardioselective β-blockers. The responsiveness of the FEV(1) to β-agonist administration decreased significantly by 13.42% after nonselective β-blockers, but did not change significantly after cardioselective β-blocker administration. CONCLUSION: This metaanalysis suggests that the use of β-blockers, especially cardioselective β-blockers, should not be contraindicated in patients with COPD.
OBJECTIVE: To assess the effect of cardioselective β-blockers on pulmonary function in patients with chronic obstructive pulmonary disease (COPD). METHODS: The Embase and MEDLINE™ databases and the Cochrane Controlled Trials Register were searched comprehensively to identify all relevant clinical trials in humans published between January 1966 and May 2011. Randomized, blinded, placebo-controlled trials that studied the effects of cardioselective β-blockers on the forced expiratory volume in 1 s (FEV(1)) and the responsiveness of the FEV(1) to β-agonist administration in patients with COPD were included in the analysis. RESULTS: Five studies were identified: four of these assessed both cardioselective and nonselective β-blockers; one assessed only cardioselective β-blockers. The FEV(1) was shown to decrease by 0.14 l with nonselective β-blockers and by 0.03 l with cardioselective β-blockers. The responsiveness of the FEV(1) to β-agonist administration decreased significantly by 13.42% after nonselective β-blockers, but did not change significantly after cardioselective β-blocker administration. CONCLUSION: This metaanalysis suggests that the use of β-blockers, especially cardioselective β-blockers, should not be contraindicated in patients with COPD.
Authors: Pietro Pirina; Elisabetta Zinellu; Marco Martinetti; Claudia Spada; Barbara Piras; Claudia Collu; Alessandro Giuseppe Fois Journal: Prim Health Care Res Dev Date: 2020-06-05 Impact factor: 1.458