Literature DB >> 2332050

Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60.

K Hashimoto1, A Kishimoto, H Aihara, I Yasuda, K Mikawa, Y Nishizuka.   

Abstract

Protein kinase C (PKC) from human promyelocytic leukemia HL-60 cells can be resolved into three fractions (peak, a, b and c) by hydroxyapatite column chromatography. Peak a and c enzymes are indistinguishable from the brain type II PKC having beta (beta I and beta II)-sequence and type III having alpha-sequence, respectively. Peak b enzyme is a previously unidentified PKC subspecies that has enzymological properties subtly different from type I (having gamma-sequence), type II and type III PKC. Upon treatment of HL-60 cells with 1 microM retinoic acid, this peak b enzyme is decreased dramatically within 24 h, whilst peak a enzyme (beta-PKC) is increased, and peak c (alpha-PKC) enzyme is slightly decreased within 48 h. The result implies that the PKC subspecies in HL-60 cells have distinct functions during cell differentiation.

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Year:  1990        PMID： 2332050     DOI： 10.1016/0014-5793(90)80698-i

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  An apparently novel protein of human leukocytes, reactive with an antibody to protein kinase C-gamma, is rapidly modified upon cell activation: initial characterization in neutrophils and their cytoplasts.

Authors:  J I Smallwood; S E Malawista
Journal:  Inflammation       Date:  1998-02       Impact factor: 4.092

Review 2.  Protein kinase C isoenzymes: divergence in signal transduction?

Authors:  H Hug; T F Sarre
Journal:  Biochem J       Date:  1993-04-15       Impact factor: 3.857

3.  Sphinganine potentiation of cellular differentiation induced by various anti-leukemia drugs in human leukemia cell line HL-60.

Authors:  B Y Yung
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

4.  Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

Authors:  Y Asaoka; K Yoshida; Y Sasaki; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

5.  Sustained activation of protein kinase C is essential to HL-60 cell differentiation to macrophage.

Authors:  H Aihara; Y Asaoka; K Yoshida; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

6.  Antisense oligodeoxynucleotide inhibition of delta protein kinase C expression accelerates induced differentiation of murine erythroleukaemia cells.

Authors:  A Pessino; M Passalacqua; B Sparatore; M Patrone; E Melloni; S Pontremoli
Journal:  Biochem J       Date:  1995-12-01       Impact factor: 3.857

7.  Tissue and cellular distribution of the extended family of protein kinase C isoenzymes.

Authors:  W C Wetsel; W A Khan; I Merchenthaler; H Rivera; A E Halpern; H M Phung; A Negro-Vilar; Y A Hannun
Journal:  J Cell Biol       Date:  1992-04       Impact factor: 10.539
  7 in total

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