Literature DB >> 2332048

Substrate-dependent inhibition of protein kinase C by specific inhibitors.

M Junco1, M J Díaz-Guerra, L Boscá.   

Abstract

Protein kinase C (PKC) and its proteolysis-derived protein kinase independent of Ca2+ and phospholipids (PKM), were purified from rat brain. By using histone H1 and protamine as substrates, we assayed the effect of several inhibitors of PKC and PKM. The inhibition turned out to be dependent on both the nature of the kinase and the type of substrate assayed. These results may help to interpret the different responses elicited by PKC inhibitors in vivo.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2332048     DOI： 10.1016/0014-5793(90)80731-w

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing.

Authors:  M H Rider; J Vandamme; E Lebeau; D Vertommen; H Vidal; G G Rousseau; J Vandekerckhove; L Hue
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

2.  Characterization of 6-phosphofructo-2-kinase from foetal-rat liver.

Authors:  P Martín-Sanz; M Cascales; L Boscá
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857

3.  Purification and characterization of G proteins from human brain: modification of GTPase activity upon phosphorylation.

Authors:  C Sauvage; J F Rumigny; M Maitre
Journal:  Mol Cell Biochem       Date:  1991-09-18       Impact factor: 3.396

4.  Intracellular signals coupled to muscarinic acetylcholine receptor activation in cerebral frontal cortex from hypoxic mice.

Authors:  T G Borda; A M Genaro; G Cremaschi
Journal:  Cell Mol Neurobiol       Date:  2000-06       Impact factor: 5.046

5.  Effects of phorbol esters and secretagogues on nitrobenzylthioinosine binding to nucleoside transporters and nucleoside uptake in cultured chromaffin cells.

Authors:  E G Delicado; R P Sen; M T Miras-Portugal
Journal:  Biochem J       Date:  1991-11-01       Impact factor: 3.857

6.  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from frog skeletal muscle: purification, kinetics and immunological properties.

Authors:  M Pyko; M H Rider; L Hue; G Wegener
Journal:  J Comp Physiol B       Date:  1993       Impact factor: 2.200

7.  Membrane components can modulate the substrate specificity of protein kinase C.

Authors:  R H Bruins; R M Epand
Journal:  Mol Cell Biochem       Date:  1995-01-26       Impact factor: 3.396

8.  Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.

Authors:  C W Lee
Journal:  Biochem J       Date:  1994-06-01       Impact factor: 3.857
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.