| Literature DB >> 23318792 |
Selin Bardak-Ozcem1, Tuncer Turhan, Oguz Resat Sipahi, Bilgin Arda, Husnu Pullukcu, Tansu Yamazhan, Meltem Isikgoz-Tasbakan, Hilal Sipahi, Sercan Ulusoy.
Abstract
In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P < 0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.Entities:
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Year: 2013 PMID: 23318792 PMCID: PMC3591926 DOI: 10.1128/AAC.01996-12
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191