| Literature DB >> 23317572 |
Chul-Hong Park1, Byung Yeoup Chung, Seung Sik Lee, Hyoung-Woo Bai, Jae Young Cho, Cheorun Jo, Tae Hoon Kim.
Abstract
Radiolytic transformation of the isoflavonoid rotenone (1) with γ-irradiation afforded two new degraded products, rotenoisins A (2) and (3). The structures of the two new rotenone derivatives were elucidated on the basis of spectroscopic methods. The new products 2 and 3 exhibited significantly enhanced inhibitory activities against pancreatic lipase and adipocyte differentiation in 3T3-L1 cells when compared to parent rotenone.Entities:
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Year: 2012 PMID： 23317572 DOI： 10.1016/j.bmcl.2012.12.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823