BACKGROUND: Respiratory syncytial virus (RSV) is the main cause of severe acute respiratory infection (SARI) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU) admission, prolonged length of stay (PLOS), and mortality in patients hospitalized with SARI caused by RSV. METHODS: This prospective cohort study included children hospitalized with SARI (according to the World Health Organization definition) and whose laboratory results proved RSV infection during the period from February 2010 to May 2011. RESULTS: Out of 240 enrolled patients, 24 patients (10%) were admitted to the ICU, 57 patients (24.3%) had a PLOS of >9 days and 12 patients (5%) died. The presence of cyanosis (P = 0.000; OR, 351.7) and lung consolidation (P = 0.006, OR, 9.3) were independent risk factors associated with ICU admission. The need for ICU admission (P = 0.000; OR, 6.1) and lung consolidation (P = 0.008, OR, 2.46) were independent risk factors associated with PLOS. The presence of an underlying congenital heart disease (P = 0.03, OR, 18.3), thrombocytopenia (P = 0.04, OR, 32.86) and mechanical ventilation (P = 0.000; OR, 449.4) were the only independent risk factors associated with mortality in our study. CONCLUSIONS: Early recognition of risk factors for complicated RSV disease on admission prompts early interventions and early ICU admissions for these children.
BACKGROUND:Respiratory syncytial virus (RSV) is the main cause of severe acute respiratory infection (SARI) in infants and young children. This study aimed to identify risk factors for intensive care unit (ICU) admission, prolonged length of stay (PLOS), and mortality in patients hospitalized with SARI caused by RSV. METHODS: This prospective cohort study included children hospitalized with SARI (according to the World Health Organization definition) and whose laboratory results proved RSV infection during the period from February 2010 to May 2011. RESULTS: Out of 240 enrolled patients, 24 patients (10%) were admitted to the ICU, 57 patients (24.3%) had a PLOS of >9 days and 12 patients (5%) died. The presence of cyanosis (P = 0.000; OR, 351.7) and lung consolidation (P = 0.006, OR, 9.3) were independent risk factors associated with ICU admission. The need for ICU admission (P = 0.000; OR, 6.1) and lung consolidation (P = 0.008, OR, 2.46) were independent risk factors associated with PLOS. The presence of an underlying congenital heart disease (P = 0.03, OR, 18.3), thrombocytopenia (P = 0.04, OR, 32.86) and mechanical ventilation (P = 0.000; OR, 449.4) were the only independent risk factors associated with mortality in our study. CONCLUSIONS: Early recognition of risk factors for complicated RSV disease on admission prompts early interventions and early ICU admissions for these children.
Authors: Nienke M Scheltema; Angela Gentile; Florencia Lucion; D James Nokes; Patrick K Munywoki; Shabir A Madhi; Michelle J Groome; Cheryl Cohen; Jocelyn Moyes; Kentigern Thorburn; Somsak Thamthitiwat; Hitoshi Oshitani; Socorro P Lupisan; Aubree Gordon; José F Sánchez; Katherine L O'Brien; Bradford D Gessner; Agustinus Sutanto; Asuncion Mejias; Octavio Ramilo; Najwa Khuri-Bulos; Natasha Halasa; Fernanda de-Paris; Márcia Rosane Pires; Michael C Spaeder; Bosco A Paes; Eric A F Simões; Ting F Leung; Maria Tereza da Costa Oliveira; Carla Cecília de Freitas Lázaro Emediato; Quique Bassat; Warwick Butt; Hsin Chi; Uzma Bashir Aamir; Asad Ali; Marilla G Lucero; Rodrigo A Fasce; Olga Lopez; Barbara A Rath; Fernando P Polack; Jesse Papenburg; Srđan Roglić; Hisato Ito; Edward A Goka; Diederick E Grobbee; Harish Nair; Louis J Bont Journal: Lancet Glob Health Date: 2017-10 Impact factor: 26.763
Authors: Ashraf Hatem; Sherif Mohamed; Usama E Abu Elhassan; Eman A M Ismael; Magda S Rizk; Amany El-Kholy; Mohamed El-Harras Journal: Multidiscip Respir Med Date: 2019-04-01