Literature DB >> 23316748

New prospects for vinblastine analogues as anticancer agents.

Romano Silvestri1.   

Abstract

Boger et al. synthesized a series of C20' urea derivatives of vinblastine that matched or exceeded the potency of vinblastine in cell growth inhibition assays. The studies demonstrated the importance of the H-bond donor on the C20' position and revealed the presence of a space surrounding the C20' substituent that tolerates a wide variety of substituents, remarkably enhancing potency of vinblastine analogues.

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Year:  2013        PMID： 23316748     DOI： 10.1021/jm400002j

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  11 in total

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3.  Highly diastereo- and enantioselective CuH-catalyzed synthesis of 2,3-disubstituted indolines.

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5.  Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water.

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Review 8.  Programmed cell death, redox imbalance, and cancer therapeutics.

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Journal:  Apoptosis       Date:  2021-07-08       Impact factor: 4.677

9.  Prediction of cancer cell sensitivity to natural products based on genomic and chemical properties.

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10.  Acetyl-11-keto-β-boswellic acid enhances the cisplatin sensitivity of non-small cell lung cancer cells through cell cycle arrest, apoptosis induction, and autophagy suppression via p21-dependent signaling pathway.

Authors:  Minghe Lv; Xibing Zhuang; Qi Zhang; Yunfeng Cheng; Duojiao Wu; Xiangdong Wang; Tiankui Qiao
Journal:  Cell Biol Toxicol       Date:  2020-06-20       Impact factor: 6.691
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