Literature DB >> 233160

Low dose fluphenazine decanoate in maintenance treatment of schizophrenia.

J M Kane, A Rifkin, F Quitkin, D Nayak, K Saraf, J R Ramos-Lorenzi, D F Klein, E J Sachar.   

Abstract

To test the clinical efficacy of low dose fluphenazine decanoate (1.25 mg to 5.0 mg biweekly), we carried out two separate experiments: (1) an open trial in 57 schizophrenic outpatients, lasting 6 months; (2) a double-blind, placebo-controlled discontinuation study in a subgroup of patients who maintained good remission throughout the entire 6-month open trial. The results suggest that lower doses of fluphenazine decanoate than those usually used may be effective in preventing psychotic relapse while keeping total cumulative dosage to a minimum.

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Year:  1979        PMID: 233160     DOI: 10.1016/0165-1781(79)90016-7

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN: 0165-1781            Impact factor:   3.222


  4 in total

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Journal:  CNS Drugs       Date:  2015-08       Impact factor: 5.749

2.  A depot neuroleptic withdrawal study. Plasma concentration of fluphenazine and flupenthixol and relapse frequency.

Authors:  B Wistedt; A Jørgensen; D Wiles
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

Review 3.  Clinical pharmacokinetics of the depot antipsychotics.

Authors:  M W Jann; L Ereshefsky; S R Saklad
Journal:  Clin Pharmacokinet       Date:  1985 Jul-Aug       Impact factor: 6.447

Review 4.  Randomized controlled trials in schizophrenia: opportunities, limitations, and trial design alternatives.

Authors:  Christoph U Correll; Taishiro Kishimoto; John M Kane
Journal:  Dialogues Clin Neurosci       Date:  2011       Impact factor: 5.986

  4 in total

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