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Literature DB >> 2331565

Chronic diazepam treatment in rats causes long-lasting changes in central [3H]-5-hydroxytryptamine and [14C]-gamma-aminobutyric acid release.

P K Hitchcott¹, S E File, M Ekwuru, M J Neal.

Abstract

The effects of chronic diazepam administration to rats on the central release of [3H]-5-hydroxytryptamine ([3H]-5-HT) and [14C]-gamma-aminobutyric acid ([14C]-GABA, ex vivo) were examined. Chronic (5 and 21 days) administration of diazepam (4 mg kg-1 i.p. daily for 21 days) reduced the K-evoked (20 mM KCl) release of [3H]-5-HT from frontal cortex by approximately 50%. Remarkably, this decrease was still present 1 week after diazepam withdrawal. Chronic diazepam treatment did not significantly affect hippocampal [3H]-5-HT release but after 21 days the K-evoked release of [14C]-GABA was more than doubled and remained elevated 30 h after withdrawal; it returned to control levels after 1 week, and decreased below control levels after 2 weeks. This study indicates that chronic diazepam treatment produces striking changes in transmitter release in rats that persist long after treatment has ceased.

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Year: 1990 PMID： 2331565 PMCID： PMC1917496 DOI： 10.1111/j.1476-5381.1990.tb14644.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

9 in total

1. Evidence for the role of brain norepinephrine and dopamine in "rebound" phenomenon seen during withdrawal after repeated exposure to benzodiazepines.

Authors: R B Rastogi; Y D Lapierre; R L Singhal
Journal: J Psychiatr Res Date: 1977 Impact factor: 4.791

2. Some neurochemical correlates of "rebound" phenomenon observed during withdrawal after long-term exposure to 1, 4-benzodiazepines.

Authors: R B Rastogi; Y D Lapierre; R L Singhal
Journal: Prog Neuropsychopharmacol Date: 1978

Review 3. The biological basis of benzodiazepine dependence.

Authors: M Lader; S File
Journal: Psychol Med Date: 1987-08 Impact factor: 7.723

Review 4. Electrophysiology of benzodiazepine receptor ligands: multiple mechanisms and sites of action.

Authors: P Polc
Journal: Prog Neurobiol Date: 1988 Impact factor: 11.685

5. 5-HT and anxiety: promises and pitfalls.

Authors: A L Johnston; S E File
Journal: Pharmacol Biochem Behav Date: 1986-05 Impact factor: 3.533

6. On the mechanism by which veratridine causes a calcium-independent release of gamma-aminobutyric acid from brain slices.

Authors: J Cunningham; M J Neal
Journal: Br J Pharmacol Date: 1981-07 Impact factor: 8.739

7. Differential actions of diazepam on the release of [3H]5-hydroxytryptamine from cortical and midbrain raphe slices in the rat.

Authors: J Collinge; C Pycock
Journal: Eur J Pharmacol Date: 1982-11-05 Impact factor: 4.432

8. Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx.

Authors: R J Marley; D W Gallager
Journal: Eur J Pharmacol Date: 1989-01-17 Impact factor: 4.432

Review 9. Tolerance to the behavioral actions of benzodiazepines.

Authors: S E File
Journal: Neurosci Biobehav Rev Date: 1985 Impact factor: 8.989

9 in total

8 in total

1. Evaluation of the dependence potential of the selective 5-H1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal.

Authors: A J Goudie; M J Leathley
Journal: Psychopharmacology (Berl) Date: 1991 Impact factor: 4.530

Review 2. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence.

Authors: N Andrews; S E File
Journal: Psychopharmacology (Berl) Date: 1993 Impact factor: 4.530

Chronic diazepam treatment in rats causes long-lasting changes in central [3H]-5-hydroxytryptamine and [14C]-gamma-aminobutyric acid release.

1. Evidence for the role of brain norepinephrine and dopamine in "rebound" phenomenon seen during withdrawal after repeated exposure to benzodiazepines.

2. Some neurochemical correlates of "rebound" phenomenon observed during withdrawal after long-term exposure to 1, 4-benzodiazepines.

Review 3. The biological basis of benzodiazepine dependence.

Review 4. Electrophysiology of benzodiazepine receptor ligands: multiple mechanisms and sites of action.

5. 5-HT and anxiety: promises and pitfalls.

6. On the mechanism by which veratridine causes a calcium-independent release of gamma-aminobutyric acid from brain slices.

7. Differential actions of diazepam on the release of [3H]5-hydroxytryptamine from cortical and midbrain raphe slices in the rat.

8. Chronic diazepam treatment produces regionally specific changes in GABA-stimulated chloride influx.

Review 9. Tolerance to the behavioral actions of benzodiazepines.

1. Evaluation of the dependence potential of the selective 5-H1A agonist ipsapirone in rats and of its effects on benzodiazepine withdrawal.

Review 2. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence.

3. Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat.

4. Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?

5. Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen.

6. Low but not high doses of buspirone reduce the anxiogenic effects of diazepam withdrawal.

7. Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze.

8. A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena.