Haerani Rasyid1, Syakib Bakri, Irawan Yusuf. 1. Department of Nutrition, Faculty of Medicine, Hasanuddin University. Jl. Perintis Kemerdekaan Km.10 Makasar, 90245, Indonesia. haeranirasyid@yahoo.co.id
Abstract
AIM: to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure. METHODS: the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method. RESULTS: this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype. CONCLUSION: this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure.
AIM: to investigate the potential association between the ACE gene polymorphism, essential hypertension and pulse pressure. METHODS: the study included 99 non-hypertensive and 104 hypertensive subjects. Hypertension is defined as systolic blood pressure 140 mmHg and/or diastolic blood pressure 90 mmHg. Pulse pressure refers to the differences between the systolic blood pressure and diastolic blood pressure. DNA amplication to examine ACE I/D polymorphism was conducted by Rigat-modification PCR method. RESULTS: this study showed no significant difference in genotype distribution and allele frequency between two groups. We found PP >60 mmHg is different between ACE gene genotype. Genotype DD has a risk of 1.8 times of having PP >60 mmHg than ID genotype while DD genotype has a risk of 4.4 times of having PP >60mg than II genotype. CONCLUSION: this study does not support that the I/D polymorphism at ACE gene locus associated with hypertension in Makassar, South-Sulawesi, Indonesia. However, there were a significant correlation with pulse pressure independent from blood pressure.
Authors: Ivna V Freire; Cezar A Casotti; Ícaro J S Ribeiro; Jonas R D Silva; Ana A L Barbosa; Rafael Pereira Journal: J Clin Hypertens (Greenwich) Date: 2018-03-09 Impact factor: 3.738