Literature DB >> 23314880

Autologous tenocyte implantation, a novel treatment for partial-thickness rotator cuff tear and tendinopathy in an elite athlete.

Allan W Wang1, Stefan Bauer, Matthew Goonatillake, William Breidahl, Ming-Hao Zheng.   

Abstract

Tendinopathy and small partial-thickness tears of the rotator cuff tendon are common presentations in sports medicine. No promising treatment has yet been established. Corticosteroid injections may improve symptoms in the short term but do not primarily treat the tendon pathology. Ultrasound-guided autologous tenocyte implantation (ATI) is a novel bioengineered treatment approach for treating tendinopathy. We report the first clinical case of ATI in a 20-year-old elite gymnast with a rotator cuff tendon injury. The patient presented with 12 months of increasing pain during gymnastics being unable to perform most skills. At 1 year after ATI the patient reported substantial improvement of clinical symptoms. Pretreatment and follow-up MRIs were reported and scored independently by two experienced musculoskeletal radiologists. Tendinopathy was improved and the partial-thickness tear healed on 3 T MRI. The patient was able to return to national-level competition.

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Mesh:

Year:  2013        PMID: 23314880      PMCID: PMC3603857          DOI: 10.1136/bcr-2012-007899

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  9 in total

1.  Cellular response and extracellular matrix breakdown in rotator cuff tendon rupture.

Authors:  Bing Wu; Jimin Chen; Tammyl Dela Rosa; Qian Yu; Allan Wang; Jiake Xu; Ming-Hao Zheng
Journal:  Arch Orthop Trauma Surg       Date:  2010-08-06       Impact factor: 3.067

2.  Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: a randomized controlled trial.

Authors:  Roberto Castricini; Umile Giuseppe Longo; Massimo De Benedetto; Nicola Panfoli; Piergiorgio Pirani; Raul Zini; Nicola Maffulli; Vincenzo Denaro
Journal:  Am J Sports Med       Date:  2010-12-15       Impact factor: 6.202

3.  Autologous tenocyte therapy for experimental Achilles tendinopathy in a rabbit model.

Authors:  Jimin Chen; Qian Yu; Bing Wu; Zhen Lin; Nathan J Pavlos; Jiake Xu; Hongwei Ouyang; Allan Wang; Ming H Zheng
Journal:  Tissue Eng Part A       Date:  2011-06-10       Impact factor: 3.845

Review 4.  Applications of platelet-rich plasma in musculoskeletal and sports medicine: an evidence-based approach.

Authors:  Rosalyn T Nguyen; Joanne Borg-Stein; Kelly McInnis
Journal:  PM R       Date:  2011-03       Impact factor: 2.298

5.  Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up.

Authors:  Pietro Randelli; Paolo Arrigoni; Vincenza Ragone; Alberto Aliprandi; Paolo Cabitza
Journal:  J Shoulder Elbow Surg       Date:  2011-06       Impact factor: 3.019

6.  Skin-derived tenocyte-like cells for the treatment of patellar tendinopathy.

Authors:  Andrew W Clarke; Faisal Alyas; Tim Morris; Claire J Robertson; Jonathan Bell; David A Connell
Journal:  Am J Sports Med       Date:  2010-12-07       Impact factor: 6.202

7.  Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection.

Authors:  Jonathan T Finnoff; Steven P Fowler; Jim K Lai; Paula J Santrach; Elaine A Willis; Yusef A Sayeed; Jay Smith
Journal:  PM R       Date:  2011-08-26       Impact factor: 2.298

8.  Autologous tenocyte therapy using porcine-derived bioscaffolds for massive rotator cuff defect in rabbits.

Authors:  Jimin M Chen; Craig Willers; Jiake Xu; Allan Wang; Ming-Hao Zheng
Journal:  Tissue Eng       Date:  2007-07

9.  Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells.

Authors:  João L Ellera Gomes; Ricardo Canquerini da Silva; Lúcia M R Silla; Marcelo R Abreu; Roberto Pellanda
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-07-20       Impact factor: 4.342

  9 in total
  11 in total

Review 1.  [Clinical management of rotator cuff tears. Current concepts in cell-based therapy strategies].

Authors:  A Ficklscherer; M F Pietschmann; M Bendiks; B P Roßbach; P E Müller
Journal:  Orthopade       Date:  2016-02       Impact factor: 1.087

2.  Tissue-engineered augmentation of a rotator cuff tendon using a reconstituted collagen scaffold: a histological evaluation in sheep.

Authors:  Craig Van Kampen; Steven Arnoczky; Patrick Parks; Eileen Hackett; Dana Ruehlman; Anthony Turner; Theodore Schlegel
Journal:  Muscles Ligaments Tendons J       Date:  2013-08-11

Review 3.  Partial Thickness Rotator Cuff Tears: Current Concepts.

Authors:  Graeme Matthewson; Cara J Beach; Atiba A Nelson; Jarret M Woodmass; Yohei Ono; Richard S Boorman; Ian K Y Lo; Gail M Thornton
Journal:  Adv Orthop       Date:  2015-06-11

4.  Reliability of a 3 T MRI protocol for objective grading of supraspinatus tendonosis and partial thickness tears.

Authors:  Stefan Bauer; Allan Wang; Rodney Butler; Michael Fallon; Robert Nairn; Charley Budgeon; William Breidahl; Ming-Hao Zheng
Journal:  J Orthop Surg Res       Date:  2014-12-18       Impact factor: 2.359

5.  Lateral Elbow Tendinopathy: Development of a Pathophysiology-Based Treatment Algorithm.

Authors:  Gev Bhabra; Allan Wang; Jay R Ebert; Peter Edwards; Monica Zheng; Ming H Zheng
Journal:  Orthop J Sports Med       Date:  2016-11-01

Review 6.  Current concepts on tenogenic differentiation and clinical applications.

Authors:  Yang Liu; Chun-Wai Suen; Jin-Fang Zhang; Gang Li
Journal:  J Orthop Translat       Date:  2017-03-18       Impact factor: 5.191

7.  Autologous Tenocyte Injection for the Treatment of Chronic Recalcitrant Gluteal Tendinopathy: A Prospective Pilot Study.

Authors:  Thomas A Bucher; Jay R Ebert; Anne Smith; William Breidahl; Michael Fallon; Tao Wang; Ming-Hao Zheng; Gregory C Janes
Journal:  Orthop J Sports Med       Date:  2017-02-21

8.  Efficacy of bone marrow stimulation in arthroscopic repair of full thickness rotator cuff tears: a meta-analysis.

Authors:  Zhuoyang Li; Yijun Zhang
Journal:  J Orthop Surg Res       Date:  2019-01-29       Impact factor: 2.359

Review 9.  Spectrum of Tendon Pathologies: Triggers, Trails and End-State.

Authors:  Sara Steinmann; Christian G Pfeifer; Christoph Brochhausen; Denitsa Docheva
Journal:  Int J Mol Sci       Date:  2020-01-28       Impact factor: 5.923

Review 10.  Identification and Distinction of Tenocytes and Tendon-Derived Stem Cells.

Authors:  Yuange Li; Tianyi Wu; Shen Liu
Journal:  Front Cell Dev Biol       Date:  2021-04-16
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