| Literature DB >> 23313563 |
Thomas Frodl1, Francesco Amico.
Abstract
OBJECTIVES: There is mounting evidence that inflammatory processes play a key role in emotional as well as cognitive dysfunctions. In this context, research employing magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MR spectroscopy) suggests a possible link between structural/functional anomalies in the brain and an increase of circulating inflammation markers. The present paper reviews this research, with particular focus on major depressive disorder (MDD), cognitive impairment in older adults, Alzheimer's disease (AD) and schizophrenia.Entities:
Keywords: (11)C-(R)-PK11195; (R)-N-(11)C-methyl-N-(1-methylpropyl)-1-(2-chlorophenyl) isoquinoline-3-carboxamide ((11)C-(R)-PK11195); ACC; AD; AI; Aging; Alzheimer's disease; BG; C-reactive protein; CA; CA3; CA4; CC; CNS; CRP; CSF; DTI; FA; GAD; GILZ; GM; GMV; HPA; IL-1; IL-10; IL-12; IL-1β; IL-6; IL-8; IgG; Inflammation; LPS; LTP; M-CSF; MCI; MCP-1; MDD; MIP-1; MPIO; MR spectroscopy; MRI; Major depression; N-methyl-d-aspartate; NMDA; NO; OFC; OMPFC; PFC; SGK; Schizophrenia; VBM; VCAM-1; WM; WMH; WMV; anterior cingulate cortex; anterior insula; basal ganglia; central nervous system; cerebrospinal fluid; cingulate cortex; cornu ammonis; cornu ammonis region 3; cornu ammonis region 4; cytokine-inducible nitric oxide synthase; dACC; diffusion tensor imaging; dorsal anterior cingulate cortex; endothelial vascular cell adhesion molecule-1; fMRI; fractional anisotropy; functional magnetic resonance imaging; glucocorticoid-induced leucine zipper; glutamic acid decarboxylase; gray matter; gray matter volume; hypothalamic–pituitary–adrenal axis; iNOS; immunoglobulin-G; interleukin-1; interleukin-10; interleukin-12; interleukin-1β; interleukin-6; interleukin-8; lipopolysaccharide; long-term potentiation; macrophage colony-stimulating factor; macrophage inflammatory peptide-1alpha; magnetic resonance imaging; magnetic resonance spectroscopy; major depressive disorder; micro-sized particles of iron oxide; mild cognitive impairment; monocyte chemo-attractant protein-1; nitric oxide; orbito medial prefrontal cortex; orbitofrontal cortex; prefrontal cortex; pro-IL-1β; pro-interleukin-1beta; sACC; sIL-4R; serum and glucocorticoid-induced kinase; soluble interleukin-4 receptor; subgenual anterior cingulate cortex; voxel-based morphometry; white matter; white matter hyperintensity; white matter volume
Mesh：
Year: 2013 PMID： 23313563 DOI： 10.1016/j.pnpbp.2012.12.013
Source DB: PubMed Journal: Prog Neuropsychopharmacol Biol Psychiatry ISSN： 0278-5846 Impact factor: 5.067