AIM OF THE STUDY: This observational study was performed to assess the cerebral tissue oxygen saturation during and after therapeutic hypothermia in comatose patients after out-of-hospital cardiac arrest. METHODS: We performed a prospective observational study on the cerebral tissue oxygen saturation (SctO(2)) in post-cardiac arrest patients treated with therapeutic hypothermia (TH) between March 2011 and April 2012. SctO(2) (measured by near-infrared spectroscopy) was non-invasively and continuously measured in 28 post-cardiac arrest patients during hypothermia and active rewarming. RESULTS: At the start of mechanically induced TH, SctO(2) was 68% (65-72) and PaCO(2) was 47.2 mmHg (36.9-51.4). SctO(2) and PaCO(2) significantly decreased to 59% (57-64; p=0.006) and 36.6 mmHg (33.9-44.7; p=0.002), respectively, within the first 3h of mechanically induced TH. Cerebral tissue oxygen saturation was significantly lower in non-survivors (n=10) compared with survivors (n=18) at 3h after induction of hypothermia (p=0.02) while the decrease in PaCO(2) was similar in both groups. During TH maintenance, SctO(2) gradually returned to baseline values (69% (63-72)) at 24h, with no differences between survivors and non-survivors (p=0.65). Carbon dioxide remained within the range of mild hypocapnia (32-38 mmHg) throughout the hypothermic period. During rewarming, SctO(2) further increased to 71% (67-78). CONCLUSIONS: Induction of TH in comatose post-CA patients changes the balance between oxygen delivery and supply. The decrease in SctO(2) was less pronounced in patients surviving to hospital discharge.
AIM OF THE STUDY: This observational study was performed to assess the cerebral tissue oxygen saturation during and after therapeutic hypothermia in comatosepatients after out-of-hospital cardiac arrest. METHODS: We performed a prospective observational study on the cerebral tissue oxygen saturation (SctO(2)) in post-cardiac arrestpatients treated with therapeutic hypothermia (TH) between March 2011 and April 2012. SctO(2) (measured by near-infrared spectroscopy) was non-invasively and continuously measured in 28 post-cardiac arrestpatients during hypothermia and active rewarming. RESULTS: At the start of mechanically induced TH, SctO(2) was 68% (65-72) and PaCO(2) was 47.2 mmHg (36.9-51.4). SctO(2) and PaCO(2) significantly decreased to 59% (57-64; p=0.006) and 36.6 mmHg (33.9-44.7; p=0.002), respectively, within the first 3h of mechanically induced TH. Cerebral tissue oxygen saturation was significantly lower in non-survivors (n=10) compared with survivors (n=18) at 3h after induction of hypothermia (p=0.02) while the decrease in PaCO(2) was similar in both groups. During TH maintenance, SctO(2) gradually returned to baseline values (69% (63-72)) at 24h, with no differences between survivors and non-survivors (p=0.65). Carbon dioxide remained within the range of mild hypocapnia (32-38 mmHg) throughout the hypothermic period. During rewarming, SctO(2) further increased to 71% (67-78). CONCLUSIONS: Induction of TH in comatose post-CA patients changes the balance between oxygen delivery and supply. The decrease in SctO(2) was less pronounced in patients surviving to hospital discharge.
Authors: Ward Eertmans; Cornelia Genbrugge; Gilles Haesevoets; Jo Dens; Willem Boer; Frank Jans; Cathy De Deyne Journal: Crit Care Date: 2017-08-22 Impact factor: 9.097
Authors: Karel Van Keer; Jan Van Keer; João Barbosa Breda; Vahid Nassiri; Cathy De Deyne; Cornelia Genbrugge; Luís Abegão Pinto; Ingeborg Stalmans; Evelien Vandewalle Journal: PLoS One Date: 2018-01-05 Impact factor: 3.240
Authors: Ward Eertmans; Cornelia Genbrugge; Margot Vander Laenen; Willem Boer; Dieter Mesotten; Jo Dens; Frank Jans; Cathy De Deyne Journal: Ann Intensive Care Date: 2018-03-02 Impact factor: 6.925
Authors: Cornelia Genbrugge; Ward Eertmans; Ingrid Meex; Margaretha Van Kerrebroeck; Noami Daems; An Creemers; Frank Jans; Willem Boer; Jo Dens; Cathy De Deyne Journal: Crit Care Date: 2016-10-13 Impact factor: 9.097