Literature DB >> 233133

Glycyrrhizic acid inhibits virus growth and inactivates virus particles.

R Pompei, O Flore, M A Marccialis, A Pani, B Loddo.   

Abstract

Screening investigations in antiviral action of plant extracts have revealed that a component of Glycyrrhiza glabra roots, found to be glycyrrhizie acid, is active against viruses. We report here that this drug inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.

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Year:  1979        PMID： 233133     DOI： 10.1038/281689a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  88 in total

1.  Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats.

Authors:  J Y Wang; Q S Zhang; J S Guo; M Y Hu
Journal:  World J Gastroenterol       Date:  2001-02       Impact factor: 5.742

2.  Effects of glycyrrhizin, an active component of licorice roots, on Candida albicans infection in thermally injured mice.

Authors:  T Utsunomiya; M Kobayashi; D N Herndon; R B Pollard; F Suzuki
Journal:  Clin Exp Immunol       Date:  1999-05       Impact factor: 4.330

Review 3.  The role of beta-glucuronidase in drug disposition and drug targeting in humans.

Authors:  B Sperker; J T Backman; H K Kroemer
Journal:  Clin Pharmacokinet       Date:  1997-07       Impact factor: 6.447

4.  Mechanism of glycyrrhizic acid inhibition of Kaposi's sarcoma-associated herpesvirus: disruption of CTCF-cohesin-mediated RNA polymerase II pausing and sister chromatid cohesion.

Authors:  Hyojeung Kang; Paul M Lieberman
Journal:  J Virol       Date:  2011-08-31       Impact factor: 5.103

5.  Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus.

Authors:  T Utsunomiya; M Kobayashi; R B Pollard; F Suzuki
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

6.  Glycyrrhizin enhances interleukin-12 production in peritoneal macrophages.

Authors:  J H Dai; Y Iwatani; T Ishida; H Terunuma; H Kasai; Y Iwakula; H Fujiwara; M Ito
Journal:  Immunology       Date:  2001-06       Impact factor: 7.397

7.  Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes.

Authors:  Y H Zhang; K Isobe; F Nagase; T Lwin; M Kato; M Hamaguchi; T Yokochi; I Nakashima
Journal:  Immunology       Date:  1993-08       Impact factor: 7.397

8.  EST analysis reveals putative genes involved in glycyrrhizin biosynthesis.

Authors:  Ying Li; Hong-Mei Luo; Chao Sun; Jing-Yuan Song; Yong-Zhen Sun; Qiong Wu; Ning Wang; Hui Yao; André Steinmetz; Shi-Lin Chen
Journal:  BMC Genomics       Date:  2010-04-28       Impact factor: 3.969

9.  Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud.

Authors:  Rajesh Arora; R Chawla; Rohit Marwah; P Arora; R K Sharma; Vinod Kaushik; R Goel; A Kaur; M Silambarasan; R P Tripathi; J R Bhardwaj
Journal:  Evid Based Complement Alternat Med       Date:  2010-10-13       Impact factor: 2.629

10.  Glycyrrhizin withdrawal followed by human lymphoblastoid interferon in the treatment of chronic hepatitis B.

Authors:  J Hayashi; W Kajiyama; A Noguchi; K Nakashima; M Hirata; S Hayashi; S Kashiwagi
Journal:  Gastroenterol Jpn       Date:  1991-12
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