| Literature DB >> 23312772 |
Marios Froudarakis1, Eleftheria Hatzimichael, Lydia Kyriazopoulou, Konstantinos Lagos, Periklis Pappas, Andreas G Tzakos, Vasilis Karavasilis, Danai Daliani, Christos Papandreou, Evangelos Briasoulis.
Abstract
Bleomycin is a key component of curative chemotherapy regimens employed in the treatment of curable cancers, such as Hodgkin lymphoma (HL) and testicular germ-cell tumours (GCT), yet its use may cause bleomycin-induced lung injury (BILI), which is associated with significant morbidity and a mortality rate of 1-3%. Diagnosis of BILI is one of exclusion and physicians involved in the care of HL and GCT patients should be alerted. Pharmacogenomic studies could contribute towards the identification of molecular predictors of bleomycin toxicity on the aim to optimize individual use of bleomycin. We review all existing data on bleomycin's most recent integrated chemical biology, molecular pharmacology and mature clinical data and provide guidelines for its safe clinical use.Entities:
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Year: 2013 PMID： 23312772 DOI： 10.1016/j.critrevonc.2012.12.003
Source DB: PubMed Journal: Crit Rev Oncol Hematol ISSN： 1040-8428 Impact factor: 6.312