| Literature DB >> 23308040 |
Manabu Wadamoto1, Marina Naodovic, Hisashi Yamamoto.
Abstract
Stereochemical aspect of asymmetric Ag-catalyzed Hosomi-Sakurai reaction with ketones has been investigated. Several allyltrimethoxysilanes have been synthesized and used for the asymmetric reaction. Remarkably, among several possible diastereomers only two are generated with high levels of diastereo- and enantioselectivities. Based on the observations for different allyltimethoxysilanes, we hypothesize formation of a single allylsilver species which undergoes addition to the ketone.Entities:
Year: 2009 PMID： 23308040 PMCID： PMC3539815 DOI： 10.1002/ejoc.200900670
Source DB: PubMed Journal: European J Org Chem ISSN： 1099-0690