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Literature DB >> 23307732

Microglia: scapegoat, saboteur, or something else?

Adriano Aguzzi¹, Ben A Barres, Mariko L Bennett.

Abstract

Microglia are resident immune cells in the brain and spinal cord. These cells provide immune surveillance and are mobilized in response to disparate diseases and injuries. Although microglial activation is often considered neurotoxic, microglia are essential defenders against many neurodegenerative diseases. It also seems increasingly likely that microglial dysfunction can underlie certain neurological diseases without an obvious immune component.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2013 PMID： 23307732 PMCID： PMC4431634 DOI： 10.1126/science.1227901

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

53 in total

Review 1. The myeloid cells of the central nervous system parenchyma.

Authors: Richard M Ransohoff; Astrid E Cardona
Journal: Nature Date: 2010-11-11 Impact factor: 49.962

2. Long-term results of stem cell transplantation for MS: a single-center experience.

Authors: A Fassas; V K Kimiskidis; I Sakellari; K Kapinas; A Anagnostopoulos; V Tsimourtou; K Sotirakoglou; A Kazis
Journal: Neurology Date: 2011-03-22 Impact factor: 9.910

3. Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Authors: Gareth R Howell; Danilo G Macalinao; Gregory L Sousa; Michael Walden; Ileana Soto; Stephen C Kneeland; Jessica M Barbay; Benjamin L King; Jeffrey K Marchant; Matthew Hibbs; Beth Stevens; Ben A Barres; Abbot F Clark; Richard T Libby; Simon W M John
Journal: J Clin Invest Date: 2011-03-07 Impact factor: 14.808

Review 4. PET tracers for the peripheral benzodiazepine receptor and uses thereof.

Authors: Pernilla J Schweitzer; Brian A Fallon; J John Mann; J S Dileep Kumar
Journal: Drug Discov Today Date: 2010-08-26 Impact factor: 7.851

5. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice.

Authors: Shau-Kwaun Chen; Petr Tvrdik; Erik Peden; Scott Cho; Sen Wu; Gerald Spangrude; Mario R Capecchi
Journal: Cell Date: 2010-05-28 Impact factor: 41.582

6. Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner.

Authors: Jan Kranich; Nike Julia Krautler; Jeppe Falsig; Boris Ballmer; Shulei Li; Gregor Hutter; Petra Schwarz; Rita Moos; Christian Julius; Gino Miele; Adriano Aguzzi
Journal: J Exp Med Date: 2010-09-13 Impact factor: 14.307

7. A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function.

Authors: John D Cahoy; Ben Emery; Amit Kaushal; Lynette C Foo; Jennifer L Zamanian; Karen S Christopherson; Yi Xing; Jane L Lubischer; Paul A Krieg; Sergey A Krupenko; Wesley J Thompson; Ben A Barres
Journal: J Neurosci Date: 2008-01-02 Impact factor: 6.167

8. Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment.

Authors: Eun Young Choi; Emmanouil Chavakis; Marcus A Czabanka; Harald F Langer; Line Fraemohs; Matina Economopoulou; Ramendra K Kundu; Alessia Orlandi; Ying Yi Zheng; Darue A Prieto; Christie M Ballantyne; Stephanie L Constant; William C Aird; Thalia Papayannopoulou; Carl G Gahmberg; Mark C Udey; Peter Vajkoczy; Thomas Quertermous; Stefanie Dimmeler; Christian Weber; Triantafyllos Chavakis
Journal: Science Date: 2008-11-14 Impact factor: 47.728

9. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

Authors: Martina M Hughes; Robert H Field; V Hugh Perry; Carol L Murray; Colm Cunningham
Journal: Glia Date: 2010-12 Impact factor: 7.452

10. Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8.

Authors: Jan Kranich; Nike Julia Krautler; Ernst Heinen; Magdalini Polymenidou; Claire Bridel; Anita Schildknecht; Christoph Huber; Marie H Kosco-Vilbois; Rolf Zinkernagel; Gino Miele; Adriano Aguzzi
Journal: J Exp Med Date: 2008-05-19 Impact factor: 14.307

351 in total

Review 1. Glia in mammalian development and disease.

Authors: J Bradley Zuchero; Ben A Barres
Journal: Development Date: 2015-11-15 Impact factor: 6.868

Review 2. Functional neural-bone marrow pathways: implications in hypertension and cardiovascular disease.

Authors: Jasenka Zubcevic; Monica M Santisteban; Teresa Pitts; David M Baekey; Pablo D Perez; Donald C Bolser; Marcelo Febo; Mohan K Raizada
Journal: Hypertension Date: 2014-03-31 Impact factor: 10.190

Review 3. Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder.

Authors: Robyn P Thom; Christopher J Keary; Michelle L Palumbo; Caitlin T Ravichandran; Jennifer E Mullett; Eric P Hazen; Ann M Neumeyer; Christopher J McDougle
Journal: Psychopharmacology (Berl) Date: 2019-05-28 Impact factor: 4.530

Review 4. Bridge between neuroimmunity and traumatic brain injury.

Authors: Matthew L Kelso; Howard E Gendelman
Journal: Curr Pharm Des Date: 2014 Impact factor: 3.116

5. Microglial exosomes facilitate α-synuclein transmission in Parkinson's disease.

Authors: Min Guo; Jian Wang; Yanxin Zhao; Yiwei Feng; Sida Han; Qiang Dong; Mei Cui; Kim Tieu
Journal: Brain Date: 2020-05-01 Impact factor: 13.501

Review 6. Myeloid Cells in the Central Nervous System.

Authors: Jasmin Herz; Anthony J Filiano; Ashtyn Smith; Nir Yogev; Jonathan Kipnis
Journal: Immunity Date: 2017-06-20 Impact factor: 31.745

Review 7. Microglia in prion diseases.

Authors: Adriano Aguzzi; Caihong Zhu
Journal: J Clin Invest Date: 2017-07-17 Impact factor: 14.808

Review 8. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity.

Authors: Dimitris N Xanthos; Jürgen Sandkühler
Journal: Nat Rev Neurosci Date: 2013-11-27 Impact factor: 34.870

9. The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia.

Authors: Panos Roussos; Pavel Katsel; Peter Fam; Weilun Tan; Dushyant P Purohit; Vahram Haroutunian
Journal: Alzheimers Dement Date: 2014-12-09 Impact factor: 21.566

Review 10. ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

Authors: Takahisa Kanekiyo; Huaxi Xu; Guojun Bu
Journal: Neuron Date: 2014-02-19 Impact factor: 17.173