| Literature DB >> 23307153 |
Takaomi Tagami1, Akihiro Takeda, Akiko Asada, Airin Aoyama, Takahiro Doi, Masami Kawaguchi, Keiji Kajimura, Yoshiyuki Sawabe, Hirotaka Obana, Katsuhiro Yamasaki.
Abstract
The official Japanese method for analyzing aristolochic acid I (AA-I) in Asiasarum root using conventional high-performance liquid chromatography (HPLC) is described in the Japanese Pharmacopoeia, Sixteenth Edition. Interfering peaks of AA-I sometimes appear after HPLC analysis of crude drugs. A selective analytical method is needed to determine definitively whether AA-I is present in crude drugs. In this study, we developed a selective method that combined solid-phase extraction and liquid chromatography/mass spectrometry (LC/MS) which may be useful for identifying AA-I in crude drugs and for quality control.Entities:
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Year: 2013 PMID: 23307153 DOI: 10.1007/s11418-012-0739-7
Source DB: PubMed Journal: J Nat Med ISSN: 1340-3443 Impact factor: 2.343