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Literature DB >> 23306773

A general solid phase method for the synthesis of depsipeptides.

Mary M Nguyen¹, Nicole Ong, Laura Suggs.

Abstract

Herein we describe the synthesis of depsipeptide sequences in which the backbone is composed of alternating esters and amides. Our methodology is based on the synthesis and protection of a depsidipeptide block, which is used as the growing unit for manual SPPS. We have explored Fmoc/OBzl and Fmoc/tBu SPPS strategies, and found the latter to be most compatible with our methodology.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23306773 DOI： 10.1039/c2ob26893k

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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Cited

7 in total

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Journal: Pharm Res Date: 2016-11-15 Impact factor: 4.200

2. Total synthesis of himastatin.

Authors: Kyan A D'Angelo; Carly K Schissel; Bradley L Pentelute; Mohammad Movassaghi
Journal: Science Date: 2022-02-24 Impact factor: 63.714

3. Charge and sequence effects on the self-assembly and subsequent hydrogelation of Fmoc-depsipeptides.

Authors: Mary M Nguyen; Kevin M Eckes; Laura J Suggs
Journal: Soft Matter Date: 2014-04-21 Impact factor: 3.679

4. β sheets not required: combined experimental and computational studies of self-assembly and gelation of the ester-containing analogue of an Fmoc-dipeptide hydrogelator.

Authors: Kevin M Eckes; Xiaojia Mu; Marissa A Ruehle; Pengyu Ren; Laura J Suggs
Journal: Langmuir Date: 2014-05-01 Impact factor: 3.882

A general solid phase method for the synthesis of depsipeptides.

1. Increased Active Tumor Targeting by An αvβ3-Targeting and Cell-Penetrating Bifunctional Peptide-Mediated Dendrimer-Based Conjugate.

2. Total synthesis of himastatin.

3. Charge and sequence effects on the self-assembly and subsequent hydrogelation of Fmoc-depsipeptides.

4. β sheets not required: combined experimental and computational studies of self-assembly and gelation of the ester-containing analogue of an Fmoc-dipeptide hydrogelator.

5. Mutually stabilizing interactions between proto-peptides and RNA.

6. Design and Evaluation of Short Self-Assembling Depsipeptides as Bioactive and Biodegradable Hydrogels.

Review 7. Marine Bioactive Peptides-An Overview of Generation, Structure and Application with a Focus on Food Sources.