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Literature DB >> 23306662

Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia.

Hirofumi Nakayama¹, Hideaki Enzan, Wataru Yasui.

Abstract

The aim of this study is to investigate the distribution and roles of podoplanin/D2-40-positive pericryptal stromal cells in superficial colorectal epithelial neoplasia. A total of 105 superficial colorectal epithelial tumors were examined: 65 tubular/tubulovillous adenomas, 32 adenocarcinomas in situ, and 8 submucosally invasive adenocarcinomas. Immunohistochemical analysis was performed using the monoclonal antibody to podoplanin/clone D2-40, which is reactive in both lymphatic endothelial cells and activated stromal cells, but negative in vascular endothelial cells. We found 50 (78 %) of 65 tubular/tubulovillous adenomas, 30 (94 %) of 32 adenocarcinomas in situ, and all 8 (100 %) submucosally invasive adenocarcinomas had podoplanin/D2-40-positive pericryptal stromal cells, whereas all normal colorectal mucosae had no podoplanin/D2-40-positive pericryptal stromal cells. The presence of podoplanin/D2-40-positive pericryptal stromal cells is associated with epithelial tumorigenesis in the colorectum.

Entities: Disease Gene

Mesh：

Substances：

Year: 2013 PMID： 23306662 DOI： 10.1007/s00795-012-0004-x

Source DB: PubMed Journal: Med Mol Morphol ISSN： 1860-1499 Impact factor: 2.309

18 in total

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5. The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.

Authors: H Nakayama; H Enzan; E Miyazaki; K Naruse; H Kiyoku; M Hiroi
Journal: Jpn J Clin Oncol Date: 1998-10 Impact factor: 3.019

6. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma.

Authors: Akikazu Kawase; Genichiro Ishii; Kanji Nagai; Takeo Ito; Tatsuya Nagano; Yukinori Murata; Tomoyuki Hishida; Mitsuyo Nishimura; Junji Yoshida; Kazuya Suzuki; Atsushi Ochiai
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7. D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans.

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8. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor.

Authors: M Miettinen; A E Lindenmayer; A Chaubal
Journal: Mod Pathol Date: 1994-01 Impact factor: 7.842

Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia.

1. A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors.

2. Prox1 function is required for the development of the murine lymphatic system.

3. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas.

4. D2-40: an additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion.

5. The role of myofibroblasts at the tumor border of invasive colorectal adenocarcinomas.

6. Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma.

7. D2-40, a novel immunohistochemical marker in differentiating dermatofibroma from dermatofibrosarcoma protuberans.

8. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor.

9. Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas.

10. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours.

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Review 2. Fibroblast Subsets in Intestinal Homeostasis, Carcinogenesis, Tumor Progression, and Metastasis.

3. Circulating tumor cell enumeration for improved screening and disease detection of patients with colorectal cancer.