UNLABELLED: Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations. OBJECTIVE: To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress. METHODS: In a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥ 4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared. RESULTS: In all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman-Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01). CONCLUSION:BCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.
RCT Entities:
UNLABELLED: Bubble continuous positive airway pressure (BCPAP) is a low cost nasal CPAP delivery system with potential benefits to developing nations. OBJECTIVE: To compare the efficacy and safety of BCPAP with ventilator-derived CPAP (VCPAP) in preterm neonates with respiratory distress. METHODS: In a randomized controlled trial, preterm neonates with Silverman-Anderson score ≥ 4 and oxygen requirement >30% within first 6 h of life were randomly allocated to BCPAP or VCPAP. Proportion of neonates with success or failure was compared. RESULTS: In all, 47 of 57 (82.5%) neonates from BCPAP group and 36 of 57 (63.2%) neonates from the VCPAP group completed CPAP successfully (p = 0.03). Neonates who failed CPAP had higher Silverman-Anderson score (p < 0.01), lower arterial to alveolar oxygenation ratio (p < 0.05) and needed surfactant more frequently (p < 0.01). CONCLUSION: BCPAP has higher success rate than VCPAP for managing preterm neonates with early onset respiratory distress, with comparable safety.
Authors: Stephen E Welty; Craig G Rusin; Larissa I Stanberry; George T Mandy; Alfred L Gest; Jeremy M Ford; Carl H Backes; C Peter Richardson; Christopher R Howard; Thomas N Hansen; Charles V Smith Journal: PLoS One Date: 2018-03-28 Impact factor: 3.240
Authors: Bernadette M Levesque; Laura Burnham; Natasha Cardoza; Marsha Adams; Robyn Cohen; Mark Mirochnick; Alan Fujii; Bharati Sinha Journal: Pediatr Qual Saf Date: 2019-08-09
Authors: Ashley R Bjorklund; Beatrice Odongkara Mpora; Marie E Steiner; Gwenyth Fischer; Cynthia S Davey; Tina M Slusher Journal: Paediatr Int Child Health Date: 2018-06-18 Impact factor: 1.990