Literature DB >> 23302869

Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands.

Wiebke Handke1, Christina Luig, Branka Popovic, Astrid Krmpotic, Stipan Jonjic, Wolfram Brune.   

Abstract

Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.

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Year:  2013        PMID： 23302869      PMCID： PMC3592122          DOI： 10.1128/JVI.02657-12

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

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