| Literature DB >> 23302762 |
Jianhao Li1, Taiping Du, Gang Zhang, Yungui Peng.
Abstract
A direct asymmetric Mannich reaction of N-unprotected 3-bromooxindoles with N-Ts-imines catalyzed by bifunctional thiourea derived from 2-substituted cinchona alkaloid was developed. Products with vicinal chiral tertiary and brominated quaternary stereogenic centers were achieved in excellent diastereo- and enantioselectivity (up to 99 : 1 dr, 99% ee).Entities:
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Year: 2013 PMID： 23302762 DOI： 10.1039/c2cc38475b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222