Literature DB >> 23301495

Cyanide antidotes for mass casualties: water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration.

Steven E Patterson1, Alexandre R Monteil, Jonathan F Cohen, Daune L Crankshaw, Robert Vince, Herbert T Nagasawa.   

Abstract

Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.

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Year:  2013        PMID： 23301495      PMCID： PMC3575131          DOI： 10.1021/jm301633x

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  15 in total

1.  INFRARED ABSORPTION RATIO METHOD FOR DETERMINATION OF TRIETHANOLAMINE SALICYLATE IN OINTMENT.

Authors:  H O HEISEY
Journal:  J Pharm Sci       Date:  1964-12       Impact factor: 3.534

2.  Enzymatic desulfuration of beta-mercaptopyruvate to pyruvate.

Authors:  A MEISTER; P E FRASER; S V TICE
Journal:  J Biol Chem       Date:  1954-02       Impact factor: 5.157

3.  Comparison of a miniaturized shake-flask solubility method with automated potentiometric acid/base titrations and calculated solubilities.

Authors:  A Glomme; J März; J B Dressman
Journal:  J Pharm Sci       Date:  2005-01       Impact factor: 3.534

Review 4.  Mercaptopyruvate sulfurtransferase as a defense against cyanide toxication: molecular properties and mode of detoxification.

Authors:  N Nagahara; T Ito; M Minami
Journal:  Histol Histopathol       Date:  1999-10       Impact factor: 2.303

5.  Cyanide toxicity in juvenile pigs and its reversal by a new prodrug, sulfanegen sodium.

Authors:  Kumar G Belani; Harpreet Singh; David S Beebe; Preeta George; Steven E Patterson; Herbert T Nagasawa; Robert Vince
Journal:  Anesth Analg       Date:  2012-03-05       Impact factor: 5.108

6.  Biological activity of 26-succinylbryostatin 1.

Authors:  G S Bignami; F Wagner; P G Grothaus; P Rustagi; D E Davis; A S Kraft
Journal:  Biochim Biophys Acta       Date:  1996-07-24

Review 7.  The mercaptopyruvate pathway in cysteine catabolism: a physiologic role and related disease of the multifunctional 3-mercaptopyruvate sulfurtransferase.

Authors:  Noriyuki Nagahara; Nori Sawada
Journal:  Curr Med Chem       Date:  2006       Impact factor: 4.530

Review 8.  Toxicology of mono-, di-, and triethanolamine.

Authors:  J B Knaak; H W Leung; W T Stott; J Busch; J Bilsky
Journal:  Rev Environ Contam Toxicol       Date:  1997       Impact factor: 7.563

Review 9.  Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?

Authors:  Noriyuki Nagahara; Qing Li; Nori Sawada
Journal:  Curr Drug Targets Immune Endocr Metabol Disord       Date:  2003-09

10.  Tissue and subcellular distribution of mercaptopyruvate sulfurtransferase in the rat: confocal laser fluorescence and immunoelectron microscopic studies combined with biochemical analysis.

Authors:  N Nagahara; T Ito; H Kitamura; T Nishino
Journal:  Histochem Cell Biol       Date:  1998-09       Impact factor: 4.304
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  10 in total

1.  A highly efficient dinuclear Cu(II) chemosensor for colorimetric and fluorescent detection of cyanide in water.

Authors:  Md Mhahabubur Rhaman; Azmain Alamgir; Bryan M Wong; Douglas R Powell; Md Alamgir Hossain
Journal:  RSC Adv       Date:  2014-10-17       Impact factor: 3.361

Review 2.  Past, present and future of cyanide antagonism research: From the early remedies to the current therapies.

Authors:  Ilona Petrikovics; Marianna Budai; Kristof Kovacs; David E Thompson
Journal:  World J Methodol       Date:  2015-06-26

Review 3.  Development of sulfanegen for mass cyanide casualties.

Authors:  Steven E Patterson; Bryant Moeller; Herbert T Nagasawa; Robert Vince; Daune L Crankshaw; Jacquie Briggs; Michael W Stutelberg; Chakravarthy V Vinnakota; Brian A Logue
Journal:  Ann N Y Acad Sci       Date:  2016-06-16       Impact factor: 5.691

4.  Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication.

Authors:  Philippe Haouzi; Marissa McCann; Nicole Tubbs; Annick Judenherc-Haouzi; Joseph Cheung; Frederic Bouillaud
Journal:  Toxicol Sci       Date:  2019-07-01       Impact factor: 4.849

5.  In-vitro mercaptopyruvate sulfurtransferase species comparison in humans and common laboratory animals.

Authors:  Bryant M Moeller; Daune L Crankshaw; Jacquie Briggs; Herbert T Nagasawa; Steven E Patterson
Journal:  Toxicol Lett       Date:  2017-04-12       Impact factor: 4.372

6.  An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.

Authors:  Eleanor M Summerhill; Gary W Hoyle; Sven-Eric Jordt; Bronwen J Jugg; James G Martin; Sadis Matalon; Steven E Patterson; David J Prezant; Alfred M Sciuto; Erik R Svendsen; Carl W White; Livia A Veress
Journal:  Ann Am Thorac Soc       Date:  2017-06

7.  Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication.

Authors:  Philippe Haouzi; Maxime Gueguinou; Takashi Sonobe; Annick Judenherc-Haouzi; Nicole Tubbs; Mohamed Trebak; Joseph Cheung; Frederic Bouillaud
Journal:  Clin Toxicol (Phila)       Date:  2018-02-16       Impact factor: 4.467

8.  Antidotal effects of methylene blue against cyanide neurological toxicity: in vivo and in vitro studies.

Authors:  Philippe Haouzi; Marissa McCann; JuFang Wang; Xue-Qian Zhang; Jianliang Song; Ilker Sariyer; Diane Langford; Maryline Santerre; Nicole Tubbs; Annick Haouzi-Judenherc; Joseph Y Cheung
Journal:  Ann N Y Acad Sci       Date:  2020-05-06       Impact factor: 5.691

9.  Sealing Effects on the Storage Stability of the Cyanide Antidotal Candidate, Dimethyl Trisulfide.

Authors:  Lóránd Kiss; Anna Duke; Kristof Kovacs; Tibor Barcza; Márton Kiss; Ilona Petrikovics; David E Thompson
Journal:  Drugs R D       Date:  2018-03

10.  Azure B as a novel cyanide antidote: Preclinical in-vivo studies.

Authors:  Haouzi Philippe; McCann Marissa; Tubbs Nicole
Journal:  Toxicol Rep       Date:  2020-10-20
  10 in total

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