Literature DB >> 2330115

Lower motor neuron disease in a patient with autoantibodies against Gal(beta 1-3)GalNAc in gangliosides GM1 and GD1b: improvement following immunotherapy.

M E Shy1, T Heiman-Patterson, G J Parry, A Tahmoush, V A Evans, P K Schick.   

Abstract

We followed a patient with a lower motor neuron form of motor neuron disease whose neurologic disorder improved following immunotherapy. The patient did not have an M protein but did have IgM antibodies to ganglioside GM1 detectable at serum titers of 1:2,000 by ELISA. These antibodies were found only in the IgM fraction with lambda light chains and immunoreacted with GD1b and Gal (beta 1-3) GalNAc.

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Year:  1990        PMID： 2330115     DOI： 10.1212/wnl.40.5.842

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  11 in total

Review 1.  Multifocal motor neuropathy.

Authors:  E Nobile-Orazio
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-06       Impact factor: 10.154

2.  A comparative trial of anti-glycoconjugate antibody assays: IgM antibodies to GM1.

Authors:  J Zielasek; G Ritter; S Magi; H P Hartung; K V Toyka
Journal:  J Neurol       Date:  1994-07       Impact factor: 4.849

3.  Long term follow up of multifocal motor neuropathy with conduction block under treatment.

Authors:  J P Azulay; P Rihet; J Pouget; F Cador; O Blin; J Boucraut; G Serratrice
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-04       Impact factor: 10.154

4.  Peripheral neuropathy associated with monoclonal IgM antibody to glycolipids with a terminal glucuronyl-3-sulfate epitope.

Authors:  P Fredman; J Lycke; O Andersen; M Vrethem; J Ernerudh; L Svennerholm
Journal:  J Neurol       Date:  1993-06       Impact factor: 4.849

5.  Anti-GM1 antibodies in patients with Guillain-Barré syndrome.

Authors:  L H van den Berg; J Marrink; A E de Jager; H J de Jong; G W van Imhoff; N Latov; S A Sadiq
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-01       Impact factor: 10.154

6.  Experimental autoimmune neuropathy with anti-GM1 antibodies and immunoglobulin deposits at the nodes of Ranvier.

Authors:  F P Thomas; W Trojaborg; C Nagy; M Santoro; S A Sadiq; N Latov; A P Hays
Journal:  Acta Neuropathol       Date:  1991       Impact factor: 17.088

7.  Motor conduction block and high titres of anti-GM1 ganglioside antibodies: pathological evidence of a motor neuropathy in a patient with lower motor neuron syndrome.

Authors:  D Adams; T Kuntzer; A J Steck; A Lobrinus; R C Janzer; F Regli
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-09       Impact factor: 10.154

8.  The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and neuropathy recognize the N-glycolylneuraminic acid containing gangliotetrahexosyl oligosaccharide.

Authors:  M Carpo; E Nobile-Orazio; V Chigorno; S Sonnino
Journal:  Glycoconj J       Date:  1995-10       Impact factor: 2.916

Review 9.  Gangliosides. Their role in clinical neurology.

Authors:  E Nobile-Orazio; M Carpo; G Scarlato
Journal:  Drugs       Date:  1994-04       Impact factor: 9.546

10.  Ganglioside antibodies: a lack of diagnostic specificity and clinical utility?

Authors:  M Weller; A Stevens; N Sommer; J Dichgans; B Kappler; H Wiethölter
Journal:  J Neurol       Date:  1992-10       Impact factor: 4.849
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