BACKGROUND: Case reports have suggested that the use of statins may be associated with an increase in the risk of interstitial lung disease (ILD). METHODS: Within a large cohort of users of respiratory medications identified in the Quebec health administrative databases during 1990-2005, we carried out a nested case-control analysis of the relationship between statins and the risk of ILD as defined by specialist visits or hospitalisations. RESULTS: The cohort included over 1.4 million patients, of which 6665 possible or probable cases of ILD were identified during follow-up. These were compared with 26 660 controls matched for age, gender and calendar time. After adjustment for confounders and comorbid conditions, there was no association between current use of statins and risk of ILD (adjusted OR 0.99, 95% CI 0.91 to 1.08). The results were similar when any use of statins within the previous 1 or 2 years was considered or when the analysis was limited to more definite cases. CONCLUSIONS: This large cohort study did not find an association between statin use and the incidence of ILD.
BACKGROUND: Case reports have suggested that the use of statins may be associated with an increase in the risk of interstitial lung disease (ILD). METHODS: Within a large cohort of users of respiratory medications identified in the Quebec health administrative databases during 1990-2005, we carried out a nested case-control analysis of the relationship between statins and the risk of ILD as defined by specialist visits or hospitalisations. RESULTS: The cohort included over 1.4 million patients, of which 6665 possible or probable cases of ILD were identified during follow-up. These were compared with 26 660 controls matched for age, gender and calendar time. After adjustment for confounders and comorbid conditions, there was no association between current use of statins and risk of ILD (adjusted OR 0.99, 95% CI 0.91 to 1.08). The results were similar when any use of statins within the previous 1 or 2 years was considered or when the analysis was limited to more definite cases. CONCLUSIONS: This large cohort study did not find an association between statin use and the incidence of ILD.
Authors: Behzad Yeganeh; Emilia Wiechec; Sudharsana R Ande; Pawan Sharma; Adel Rezaei Moghadam; Martin Post; Darren H Freed; Mohammad Hashemi; Shahla Shojaei; Amir A Zeki; Saeid Ghavami Journal: Pharmacol Ther Date: 2014-02-26 Impact factor: 12.310
Authors: Daniela M Santos; Lorena Pantano; Gina Pronzati; Paula Grasberger; Clemens K Probst; Katharine E Black; Jillian J Spinney; Lida P Hariri; Royale Nichols; Yufei Lin; Michael Bieler; Peter Seither; Paul Nicklin; David Wyatt; Andrew M Tager; Benjamin D Medoff Journal: Am J Respir Cell Mol Biol Date: 2020-04 Impact factor: 6.914
Authors: Jennifer L Larson-Casey; Mudit Vaid; Linlin Gu; Chao He; Guo-Qiang Cai; Qiang Ding; Dana Davis; Taylor F Berryhill; Landon S Wilson; Stephen Barnes; Jeffrey D Neighbors; Raymond J Hohl; Kurt A Zimmerman; Bradley K Yoder; Ana Leda F Longhini; Vidya Sagar Hanumanthu; Ranu Surolia; Veena B Antony; A Brent Carter Journal: J Clin Invest Date: 2019-11-01 Impact factor: 19.456
Authors: Mark J Hamblin; Michael Eberlein; Katharine Black; Robert Hallowell; Samuel Collins; Yee Chan-Li; Maureen R Horton Journal: Int J Biomed Sci Date: 2014-09
Authors: Matthieu Storme; Alexandre Semionov; Deborah Assayag; Michael Lefson; Darlene Kitty; David Dannenbaum; Jill Torrie; Pierre Lejeune; Elizabeth Robinson; Faiz Ahmad Khan Journal: PLoS One Date: 2017-09-08 Impact factor: 3.240