Literature DB >> 23299246

A functional role of the cyclin-dependent kinase inhibitor 1 (p21(WAF1/CIP1)) for neuronal preconditioning.

Philipp Mergenthaler1, Claudia Muselmann, Juliane Sünwoldt, Nickolay K Isaev, Tadeusz Wieloch, Ulrich Dirnagl, Andreas Meisel, Karsten Ruscher.   

Abstract

Hypoxic preconditioning is thought to rely on gene products regulated by hypoxia-inducible factor (HIF)-1. Here, we show that the HIF-1 target gene cyclin-dependent kinase inhibitor 1, p21(WAF1/CIP1), is essential for neuroprotection by hypoxic/aglycemic or erythropoietin preconditioning using wild-type and p21(WAF1/CIP1)-deficient neurons. Furthermore, overexpression of wild-type p21(WAF1/CIP1) or phospho-mutants significantly increased cell death after hypoxia/aglycemia. Moreover, deferoxamine-induced endogenous tolerance did not involve p21(WAF1/CIP1) expression in cortical neurons. Our data suggest that balanced expression and potentially posttranslational regulation of p21(WAF1/CIP1) is required for hypoxic preconditioning.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23299246      PMCID： PMC3587824          DOI： 10.1038/jcbfm.2012.213

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  15 in total

Review 1.  Ischemic injury and faulty gene transcripts in the brain.

Authors:  P K Liu; R G Grossman; C Y Hsu; C S Robertson
Journal:  Trends Neurosci       Date:  2001-10       Impact factor: 13.837

2.  The tumor suppressor p53 and its response gene p21WAF1/Cip1 are not markers of neuronal death following transient global cerebral ischemia.

Authors:  G Tomasevic; F Kamme; P Stubberöd; M Wieloch; T Wieloch
Journal:  Neuroscience       Date:  1999-03       Impact factor: 3.590

3.  WAF1, a potential mediator of p53 tumor suppression.

Authors:  W S el-Deiry; T Tokino; V E Velculescu; D B Levy; R Parsons; J M Trent; D Lin; W E Mercer; K W Kinzler; B Vogelstein
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

4.  Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21(waf1/cip1), and erythropoietin.

Authors:  K Zaman; H Ryu; D Hall; K O'Donovan; K I Lin; M P Miller; J C Marquis; J M Baraban; G L Semenza; R R Ratan
Journal:  J Neurosci       Date:  1999-11-15       Impact factor: 6.167

5.  Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state.

Authors:  Philipp Mergenthaler; Anja Kahl; Anne Kamitz; Vincent van Laak; Katharina Stohlmann; Susanne Thomsen; Heiko Klawitter; Ingo Przesdzing; Lars Neeb; Dorette Freyer; Josef Priller; Tony J Collins; Dirk Megow; Ulrich Dirnagl; David W Andrews; Andreas Meisel
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-10       Impact factor: 11.205

6.  Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model.

Authors:  Karsten Ruscher; Dorette Freyer; Maria Karsch; Nikolai Isaev; Dirk Megow; Birgit Sawitzki; Josef Priller; Ulrich Dirnagl; Andreas Meisel
Journal:  J Neurosci       Date:  2002-12-01       Impact factor: 6.167

7.  Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.

Authors:  Jun Zhan; John B Easton; Shile Huang; Ashutosh Mishra; Limin Xiao; Eilyn R Lacy; Richard W Kriwacki; Peter J Houghton
Journal:  Mol Cell Biol       Date:  2007-02-26       Impact factor: 4.272

8.  Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro.

Authors:  Konstantin Prass; Karsten Ruscher; Maria Karsch; Nikolay Isaev; Dirk Megow; Josef Priller; Anna Scharff; Ulrich Dirnagl; Andreas Meisel
Journal:  J Cereb Blood Flow Metab       Date:  2002-05       Impact factor: 6.200

9.  Resistance to Fas-mediated apoptosis: activation of caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP.

Authors:  A Suzuki; Y Tsutomi; K Akahane; T Araki; M Miura
Journal:  Oncogene       Date:  1998-08-27       Impact factor: 9.867

10.  Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons.

Authors:  K Ruscher; N Isaev; G Trendelenburg; M Weih; L Iurato; A Meisel; U Dirnagl
Journal:  Neurosci Lett       Date:  1998-09-25       Impact factor: 3.046
View more
  3 in total

1.  Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats.

Authors:  William J McBride; Mark W Kimpel; Jeanette N McClintick; Zheng-Ming Ding; Howard J Edenberg; Tiebing Liang; Zachary A Rodd; Richard L Bell
Journal:  Pharmacol Biochem Behav       Date:  2013-12-16       Impact factor: 3.533

2.  JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression.

Authors:  Sathi Mallick; Santosh R D'Mello
Journal:  J Biol Chem       Date:  2014-10-20       Impact factor: 5.157

Review 3.  Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases.

Authors:  Jia Liu; Yakun Gu; Mengyuan Guo; Xunming Ji
Journal:  CNS Neurosci Ther       Date:  2021-08       Impact factor: 5.243
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.