Literature DB >> 2329919

Purification of L-[3H]nicotine eliminates low affinity binding.

E Romm1, P M Lippiello, M J Marks, A C Collins.   

Abstract

Some studies of L-[3H]nicotine binding to rodent and human brain tissue have detected two binding sites as evidenced by nonlinear Scatchard plots. Evidence presented here indicates that the low affinity binding site is not stereospecific, is not inhibited by low concentrations of cholinergic agonists and is probably due to breakdown products of nicotine since purification of the L-[3H]nicotine eliminates the low affinity site.

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Year:  1990        PMID： 2329919     DOI： 10.1016/0024-3205(90)90095-9

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  8 in total

1.  86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization.

Authors:  Michael J Marks; Natalie M Meinerz; Robert W B Brown; Allan C Collins
Journal:  Biochem Pharmacol       Date:  2010-06-30       Impact factor: 5.858

2.  UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.

Authors:  C G Sharples; S Kaiser; L Soliakov; M J Marks; A C Collins; M Washburn; E Wright; J A Spencer; T Gallagher; P Whiteaker; S Wonnacott
Journal:  J Neurosci       Date:  2000-04-15       Impact factor: 6.167

3.  Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine.

Authors:  H el-Bizri; P B Clarke
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

4.  The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion.

Authors:  P B Clarke; I Chaudieu; H el-Bizri; P Boksa; M Quik; B A Esplin; R Capek
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739

5.  Adrenalectomy reverses chronic injection-induced tolerance to nicotine.

Authors:  E A Grun; J R Pauly; A C Collins
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

6.  Tolerance to nicotine following chronic treatment by injections: a potential role for corticosterone.

Authors:  J R Pauly; E U Grun; A C Collins
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

7.  Inhibition by dizocilpine (MK-801) of striatal dopamine release induced by MPTP and MPP+: possible action at the dopamine transporter.

Authors:  P B Clarke; M Reuben
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739

8.  Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation.

Authors:  F A Abdulla; E Bradbury; M R Calaminici; P M Lippiello; S Wonnacott; J A Gray; J D Sinden
Journal:  Psychopharmacology (Berl)       Date:  1996-04       Impact factor: 4.530
  8 in total

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