BACKGROUND: Recent advances in very high frame rate use of ultrasonography have enabled the application of two-dimensional speckle-tracking echocardiography (STE) to small animal cardiac functional assessments. In this study, two-dimensional STE was applied to a rat model of hypertensive heart failure with preserved ejection fraction to clarify consequences of left ventricular (LV) wall deformation in the progression of heart failure with preserved ejection fraction. METHODS: STE was performed every 2 weeks in Dahl salt-sensitive rats fed a 0.3% (control group) or 8% (hypertension [HT] group) sodium chloride diet from 6 to 14 weeks of age. Longitudinal, radial, and circumferential global strain and strain rate were measured, and the time courses of these parameters were observed. RESULTS: Deterioration of longitudinal strain occurred in the early phase of the progression of LV hypertrophy and continued to worsen until congestive heart failure developed (longitudinal strain in the HT group: 25 ± 3% at 10 weeks, 21 ± 4% at 12 weeks, and 18 ± 2% at 14 weeks; longitudinal strain in controls was preserved during the experimental period). At 12 weeks, radial strain (HT group, 35 ± 7%; controls, 41 ± 10%) had deteriorated at the late stage of manifest diastolic dysfunction. Throughout the experiments, circumferential strain was preserved (HT group, 35 ± 6%; control group, 35 ± 5%), and no significant increase in short-axis function was observed. CONCLUSIONS: STE is applicable to the small animal heart and detected LV wall long-axis dysfunction preceding short-axis dysfunction or overt congestive heart failure in the progression of hypertensive LV hypertrophy in a rat model.
BACKGROUND: Recent advances in very high frame rate use of ultrasonography have enabled the application of two-dimensional speckle-tracking echocardiography (STE) to small animal cardiac functional assessments. In this study, two-dimensional STE was applied to a rat model of hypertensive heart failure with preserved ejection fraction to clarify consequences of left ventricular (LV) wall deformation in the progression of heart failure with preserved ejection fraction. METHODS:STE was performed every 2 weeks in Dahl salt-sensitive rats fed a 0.3% (control group) or 8% (hypertension [HT] group) sodium chloride diet from 6 to 14 weeks of age. Longitudinal, radial, and circumferential global strain and strain rate were measured, and the time courses of these parameters were observed. RESULTS: Deterioration of longitudinal strain occurred in the early phase of the progression of LV hypertrophy and continued to worsen until congestive heart failure developed (longitudinal strain in the HT group: 25 ± 3% at 10 weeks, 21 ± 4% at 12 weeks, and 18 ± 2% at 14 weeks; longitudinal strain in controls was preserved during the experimental period). At 12 weeks, radial strain (HT group, 35 ± 7%; controls, 41 ± 10%) had deteriorated at the late stage of manifest diastolic dysfunction. Throughout the experiments, circumferential strain was preserved (HT group, 35 ± 6%; control group, 35 ± 5%), and no significant increase in short-axis function was observed. CONCLUSIONS:STE is applicable to the small animal heart and detected LV wall long-axis dysfunction preceding short-axis dysfunction or overt congestive heart failure in the progression of hypertensive LV hypertrophy in a rat model.
Authors: Grace Casaclang-Verzosa; Maurice Enriquez-Sarano; Hector R Villaraga; Jordan D Miller Journal: J Vis Exp Date: 2017-02-14 Impact factor: 1.355
Authors: Pierpaolo Pellicori; Anna Kallvikbacka-Bennett; Olga Khaleva; Valentina Carubelli; Pierluigi Costanzo; Teresa Castiello; Kenneth Wong; Jufen Zhang; John G F Cleland; Andrew L Clark Journal: Int J Cardiovasc Imaging Date: 2013-10-23 Impact factor: 2.357
Authors: Omar Issa; Julio G Peguero; Carlos Podesta; Denisse Diaz; Javier De La Cruz; Daniela Pirela; Juan Carlos Brenes Journal: J Cardiovasc Echogr Date: 2017 Jan-Mar